Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
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Journal ArticleDOI
Three-dimensional mapping of oxygen tension in cortical arterioles before and after occlusion
S. M. Shams Kazmi,Anthony Salvaggio,Arnold D. Estrada,Michael A. Hemati,Nazariy K. Shaydyuk,Emannuel Roussakis,Theresa A. Jones,Sergei A. Vinogradov,Andrew K. Dunn +8 more
TL;DR: In this article, a combined optical system using two-photon phosphorescence lifetime and fluorescence microscopy (2PLM) was used to characterize the partial pressure of oxygen (pO2) in single descending cortical arterioles in the mouse brain before and after generating a targeted photothrombotic occlusion.
Journal ArticleDOI
Nephron blood flow dynamics measured by laser speckle contrast imaging.
Niels-Henrik Holstein-Rathlou,Olga Sosnovtseva,Alexey N. Pavlov,William A. Cupples,Charlotte Mehlin Sorensen,Donald J. Marsh +5 more
TL;DR: Laser speckle contrast imaging is used to measure the blood flow dynamics of 50-100 nephrons simultaneously on the renal surface of anesthetized rats to detect synchronized TGF oscillations, which may take place among nephron not immediately adjacent on the surface of the kidney.
Journal ArticleDOI
Multi-channel deep tissue flowmetry based on temporal diffuse speckle contrast analysis
Renzhe Bi,Jing Dong,Kijoon Lee +2 more
TL;DR: Time-domain DSCA is introduced where temporal statistics are used for speckle contrast calculation and results in the same deep tissue flow measurement and is especially suitable for multi-channel real-time flowmetry.
Journal ArticleDOI
Optical coherence tomography for longitudinal monitoring of vasculature in scars treated with laser fractionation
Peijun Gong,Shaghayegh Es'haghian,Karl-Anton Harms,Alexandra Murray,Suzanne Rea,Suzanne Rea,Brendan F. Kennedy,Fiona M. Wood,Fiona M. Wood,David D. Sampson,Robert A. McLaughlin +10 more
TL;DR: This study establishes the feasibility of OCT imaging for quantitative longitudinal monitoring of vasculature in scar treatment through reliable co-location of the imaging field of view across multiple imaging sessions, and compensation for motion artifact.
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Microvascular imaging of the skin
TL;DR: In this review article, a number of imaging techniques are summarized that have been utilized to investigate the microvasculature of skin, along with their advantages, disadvantages and future perspectives in preclinical and clinical settings.
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