Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
Citations
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Sugar-Induced Skin Optical Clearing: From Molecular Dynamics Simulation to Experimental Demonstration
TL;DR: A comparison of laser speckle imaging of dermal blood flow after topical treatment with fructose, a penetration enhancer, and a mixture of the two to rat skin in vivo demonstrated that the mixture causes the largest increase in the resolution and contrast.
Journal ArticleDOI
Intraoperative Assessment of Parathyroid Viability using Laser Speckle Contrast Imaging.
TL;DR: LSCI shows promise as a real-time, contrast-free, objective method for helping reduce hypoparathyroidism after thyroid surgery.
Journal ArticleDOI
Predicting the ischemic infarct volume at the first minute after occlusion in rodent stroke model by laser speckle imaging of cerebral blood flow
TL;DR: An on-line laser speckle imaging (LSI) system is implemented, which could provide real time high spatio-temporal resolution CBF information before, during, and immediately after the rat MCAO surgery, and finds a significant correlation between the affected area with 50% CBF reduction at the first minute after occlusion with the infarct volume.
Journal ArticleDOI
Quantitative laser speckle flowmetry of the in vivo microcirculation using sidestream dark field microscopy.
TL;DR: Applying SDF-LSCI in vitro and in vivo allows direct comparison between speckle contrast decorrelation and flow velocities, while imaging the phantom and microcirculation architecture, which resulted in a novel analysis approach that distinguishes decorrelation due to flow from other additive decorrelation sources.
Journal ArticleDOI
HSP27 protects the blood-brain barrier against ischemia-induced loss of integrity.
Rehana K. Leak,Lili Zhang,Lili Zhang,R. Anne Stetler,R. Anne Stetler,Zhongfang Weng,Zhongfang Weng,Peiying Li,G. Brandon Atkins,Yanqin Gao,Jun Chen,Jun Chen,Jun Chen +12 more
TL;DR: It is shown that HSP27 transgenic overexpression also maintains the integrity of the BBB in mice subjected to tMCAO, revealing a novel role for H SP27 in attenuating ischemia/reperfusion injury - the maintenance of BBB integrity.
References
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