Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
Citations
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Journal ArticleDOI
cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice.
Maria Shvedova,Maxim M. Litvak,Jesse D. Roberts,Dai Fukumura,Tomoaki Suzuki,Ikbal Sencan,Ge Li,Paula Reventun,Emmanuel S. Buys,Hyung-Hwan Kim,Sava Sakadžić,Cenk Ayata,Paul L. Huang,Robert Feil,Dmitriy N. Atochin +14 more
TL;DR: A protective role of cGKI is identified in vascular smooth muscle cells during ischemic stroke injury for the first time and was found to be independent of gender and was mediated via improved reperfusion.
Journal ArticleDOI
Enhancing vascular visualization in laser speckle contrast imaging of blood flow using multi-focus image fusion.
TL;DR: A multi-focus image fusion method based on contourlet transform is introduced to reduce the misfocus effects in LSCI and suggest that this method can provide an all-in-focus blood flow image, which is convenient to observe the blood vessels.
Journal ArticleDOI
Multi-scale laser speckle contrast imaging of microcirculatory vasoreactivity.
TL;DR: In this article , a multi-scale laser speckle contrast imaging system was proposed to study vasoreactivity in renal microcirculation, which combines high resolution (small field of view) to segment blood flow in individual vessels with low resolution (large field-of-view) to monitor global blood flow changes across the renal surface.
Proceedings ArticleDOI
Thermal Ghost Imaging with Averaged Speckle Patterns
Zhimin Shi,Petros Zerom,Malcolm N. O’Sullivan,Kam Wai Clifford Chan,Molly Krogstad,Jeffrey H. Shapiro,Robert W. Boyd +6 more
TL;DR: In this paper, the authors present a theory with experimental demonstration that a thermal ghost imaging system can maintain its image quality even when it uses slow detectors which only respond to intensity-averaged, or "blurred" speckle patterns.
Journal ArticleDOI
Microfluidic-based laser speckle contrast imaging of erythrocyte flow and magnetic nanoparticle retention in blood
TL;DR: The microfluidic-based LSCI measurement represents a simple yet controllable experimental model for evaluating the variations in different hemorheological conditions in vitro and has a strong potential as an easy-to-use tool for investigating local MNP retention and hemodynamic changes.
References
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