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Laser speckle contrast imaging in biomedical optics

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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.
Abstract
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.

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References
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BookDOI

Dynamic Light Scattering

Robert Pecora
Journal ArticleDOI

Pathobiology of ischaemic stroke: an integrated view

TL;DR: This article provides a framework that can be used to generate testable hypotheses and treatment strategies that are linked to the appearance of specific pathophysiological events within the ischaemic brain.
Book

Statistical Optics

Journal ArticleDOI

Spreading depression of activity in the cerebral cortex

TL;DR: In this article, an interesting response elicited by electrical stimulation was noticed in the cortex of rabbits, and the distinctive feature of this response was a marked, enduring reduction of the "spontaneous" electrical activity of the cortex.
ReportDOI

Statistical properties of laser sparkle patterns

TL;DR: In this article, the first order statistics of the observed electric-field strength, the observed light intensity, and observed light phase are examined, and the autocorrelation functions of the complex field and intensity processes are investigated, and that of the electric field is found to be proportional to the Fourier transform of the light intensity distribution incident on the scattering surface.
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