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Laser speckle contrast imaging in biomedical optics

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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.
Abstract
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.

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Citations
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Self–healing Thermal Interface Materials

N. Zhong
TL;DR: In this paper, the introduction of self-healing concepts into polymer-based thermal interface materials (TIMs) to increase their reliability and service lifetime has been discussed, and each chapter targets one of the scientific issues that are related to the development of commercial selfhealing TIMs.
Journal ArticleDOI

Assessment of flow within developing chicken vasculature and biofabricated vascularized tissues using multimodal imaging techniques.

TL;DR: In this article, the authors developed laser speckle contrast imaging (LSCI) and side-stream dark field microscopy (SDF) systems to map the vascular organization, spatio-temporal blood flow fluctuations as well as erythrocytes movements within individual blood vessels of developing chick embryo, cultured within an artificial eggshell system.
Dissertation

Low bandwidth laser doppler blood flowmetry

TL;DR: Bayesian Inference has been used to show that the Pareto distribution is a likely model for the LDBF power spectrum, despite often being cited as exponential, and to correct the blood flow output towards gold-standard values.
Journal ArticleDOI

Temporal change of retinal nerve fiber layer reflectance speckle in normal and hypertensive retinas

TL;DR: Temporal change of retinal nerve fiber layer reflectance speckle in retinas with ocular hypertensive (OHT) damage and in control retinas from untreated eyes may offer a method for detecting functional abnormality of the RNFL.
Proceedings ArticleDOI

An adaptive-coherence light source for hyperspectral, topographic, and flow-contrast imaging.

TL;DR: A novel endoscopic light source design that retains the ability to offer white light and narrow band illumination modes with improved power efficiency, a reduced size, and longer lifetimes compared to conventional endoscopic arc lamp sources shows promise for increasing the detection of subtle lesions in routine colonoscopy screening.
References
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BookDOI

Dynamic Light Scattering

Robert Pecora
Journal ArticleDOI

Pathobiology of ischaemic stroke: an integrated view

TL;DR: This article provides a framework that can be used to generate testable hypotheses and treatment strategies that are linked to the appearance of specific pathophysiological events within the ischaemic brain.
Book

Statistical Optics

Journal ArticleDOI

Spreading depression of activity in the cerebral cortex

TL;DR: In this article, an interesting response elicited by electrical stimulation was noticed in the cortex of rabbits, and the distinctive feature of this response was a marked, enduring reduction of the "spontaneous" electrical activity of the cortex.
ReportDOI

Statistical properties of laser sparkle patterns

TL;DR: In this article, the first order statistics of the observed electric-field strength, the observed light intensity, and observed light phase are examined, and the autocorrelation functions of the complex field and intensity processes are investigated, and that of the electric field is found to be proportional to the Fourier transform of the light intensity distribution incident on the scattering surface.
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