Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
Citations
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Journal ArticleDOI
Cardiac pulsatility mapping and vessel type identification using laser speckle contrast imaging
TL;DR: Laser speckle contrast imaging is applied to images with high spatial resolution in the high frequency harmonics of cardiac activity in the cerebral cortex of a mouse to reveal vessel dependent variation in the cardiac pulse activity and use this information to automatically identify arteries and veins.
Journal ArticleDOI
Correcting speckle contrast at small speckle size to enhance signal to noise ratio for laser speckle contrast imaging.
TL;DR: The results indicate the possibility of selecting a relatively large aperture to simultaneously ensure sufficient light intensity and high accuracy and signal to noise ratio, making the laser speckle contrast imaging more flexible.
Journal ArticleDOI
Improved collateral flow and reduced damage after remote ischemic perconditioning during distal middle cerebral artery occlusion in aged rats
TL;DR: Improved flow was associated with reduced early ischemic damage in RIPerC treated aged rats relative to controls and supports further investigation as an adjuvant therapy to recanalization therapy and a protective treatment to maintain tissue viability prior to reperfusion.
Journal ArticleDOI
Chronic wide-field imaging of brain hemodynamics in behaving animals.
TL;DR: A novel standalone micro-imager for monitoring the cerebral blood flow (CBF) and total hemoglobin (HbT) activities in freely moving animals using the laser speckle contrast imaging (LSCI) and optical intrinsic signal (OIS) methods is presented.
Journal ArticleDOI
A reduced gastric corpus microvascular blood flow during Ivor-Lewis esophagectomy detected by laser speckle contrast imaging technique.
Rikard Ambrus,Lars Bo Svendsen,Niels H. Secher,Kim Rünitz,Hans-Jørgen Frederiksen,Morten Bo Søndergaard Svendsen,Mette Siemsen,Steen C. Kofoed,Michael Patrick Achiam +8 more
TL;DR: LSCI provides an option for real-time assessment of gastric microcirculation and could form basis for intraoperative stabilization of the microcirculations and identify a reduced micro Circulation at the corpus area during open Ivor-Lewis esophagectomy.
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