Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
Citations
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Towards non-contact photoacoustic imaging [review].
TL;DR: This paper presents a brief overview of current non-contact photoacoustic detection techniques with an emphasis on all-optical detection methods and their associated physical mechanisms.
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Choosing a laser for laser speckle contrast imaging
TL;DR: It is shown that commonly used semiconductor laser diodes have a larger than desired spectral width that results in a significantly reduced speckle contrast compared with ideal narrow band lasers, resulting in a reduced signal-to-noise ratio for estimating changes in the motion of scattering particles.
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A curvature-tunable random laser.
TL;DR: This study investigated whether the transport mean free path of emitted photons within disordered scatterers composed of ZnO nanowires is tunable by a curvature bending applied to the flexible polyethylene terephthalate (PET) substrate underneath, thereby creating a unique light source that can be operated above and below the lasing threshold for desirable spectral emissions.
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Transcranial optical vascular imaging (TOVI) of cortical hemodynamics in mouse brain.
TL;DR: A novel, minimally invasive method for vascular imaging through the sufficiently transparent intact skull of young mice that combines laser speckle and fluorescent imaging with dynamic color mapping and image fusion and may become an important tool for assessment of brain hemodynamics in preclinical studies.
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A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery.
John T. Nguyen,Samuel J. Lin,Adam M. Tobias,Sylvain Gioux,Amaan Mazhar,David J. Cuccia,Yoshitomo Ashitate,Alan Stockdale,Rafiou Oketokoun,Nicholas J. Durr,Lorissa A. Moffitt,Anthony J. Durkin,Bruce J. Tromberg,John V. Frangioni,Bernard T. Lee +14 more
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