Laser speckle contrast imaging in biomedical optics
David A. Boas,Andrew K. Dunn +1 more
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TLDR
The underlying physics of speckle contrast imaging is reviewed, recent developments to improve the quantitative accuracy of blood flow measures are discussed and applications in neuroscience, dermatology and ophthalmology are reviewed.Abstract:
First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.read more
Citations
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Functional laser speckle imaging of cerebral blood flow under hypothermia
TL;DR: The combination of LSI and TCA is a high-resolution functional imaging method to investigate the spatiotemporal neurovascular coupling in both normal and pathological brain functions and found a delayed response peak and a prolonged response window under hypothermia.
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Quantitative model of diffuse speckle contrast analysis for flow measurement.
TL;DR: The influence of optical property on the measurements of the Brownian diffusion coefficient was quantified as a consequence of the fact that the slope of this linear approximation was demonstrated to be equal to the inverse of correlation time of the speckle.
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Label-free optical imaging of membrane potential
TL;DR: This work reviews major contrast mechanisms used for label-free voltage imaging and discusses several recent exciting advances that could potentially enable membrane potential imaging in mammalian neurons at high speed and high sensitivity.
Journal ArticleDOI
Simple correction factor for laser speckle imaging of flow dynamics
TL;DR: A new model expression for integrated speckle contrast is presented, which accounts not only for temporal integration but spatial integration, too, due to the finite size of the pixel of the CCD camera; as a result, it is found that a correction factor should be introduced to the measured speckel contrast to properly determine τ(C); otherwise, the measured blood's speed is overestimated.
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Tutorial on laser speckle rheology: technology, applications, and opportunities
TL;DR: The fast-paced technological advancements have primed the LSR for widespread applications in diagnosis and therapeutic monitoring, as demonstrated here, in cardiovascular disease, coagulation disorders, and tumor malignancies.
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