Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
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Patent
Process for the production of an abuse-proofed dosage form
TL;DR: In this paper, a process for the production of abuse-proofed, thermoformed dosage forms containing, apart from one or more active ingredients with potential for abuse and optionally physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of at least 500 N.
Journal ArticleDOI
Enhancement in antifungal activity of eugenol in immunosuppressed rats through lipid nanocarriers
Anuj Garg,Sanjay Singh +1 more
TL;DR: Eugenol loaded solid lipid nanoparticles was prepared and characterized for particle size, polydispersity index, zeta potential, encapsulation efficiency, in vitro release and in vivo antifungal activity and the in vivo study results indicate improvement in the antif fungus activity of eugenol.
Journal ArticleDOI
Modeling drug release from a layered double hydroxide-ibuprofen complex
Ricardo Rojas,María Celeste Palena,Alvaro F. Jimenez-Kairuz,Ruben H. Manzo,Carla E. Giacomelli +4 more
TL;DR: Three release mechanisms accounted for the rate and extent of the drug release: ion exchange, desorption and weathering, and different solubility of the anionic and non-ionic ibuprofen species explained the release behavior for particulate solid and hydrogel formulations.
Journal ArticleDOI
An overview on the mathematical modeling of hydrogels' behavior for drug delivery systems.
TL;DR: It was found that, despite the drug release fitting models (i.e. Higuchi's equation) are the most abundant, their use for HBSs is decreasing in the last years and luckily, considering the limiting assumption on which they were built, they will be confined to simple mathematical fitting equations.
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Formulation and in vitro Evaluation of Eudragit ® Microspheres of Stavudine
TL;DR: In this article, the authors formulated and evaluated microencapsulated controlled release preparations of a highly water-soluble drug, stavudine, using Copolymers synthesized from acrylic and methacrylic acid esters (Eudragit RS 100 and RL 100) as the retardant material.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.