Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
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Patent
Tamper resistant dosage form comprising an anionic polymer
TL;DR: In this article, a pharmaceutical dosage form exhibiting a breaking strength of at least 500 N, said dosage form containing - a pharmacologically active ingredient (A); - a physiologically acceptable polymer (B) obtainable by polymerization of a monomer composition comprising an ethylenically unsaturated monomer bearing an anionic functional group, in protonated form or a physically acceptable salt thereof.
Journal ArticleDOI
Solid lipid nanoparticles and nanosuspension formulation of Saquinavir: preparation, characterization, pharmacokinetics and biodistribution studies.
TL;DR: The relative bioavailabilities for SNS and SQSLN were 37.39% and 66.53%, respectively, compared to 18.87% bioavailability obtained after administration of SMS, indicating suitability of nanoparticulate formulations for improving bioavailability.
Journal ArticleDOI
Modulating drug release and matrix erosion of alginate matrix capsules by microenvironmental interaction with calcium ion.
TL;DR: A small change in drug release and matrix erosion was observed, which suggests that microenvironmental interaction between hydrated SA and calcium ion in distilled water could be created in the formulations prepared using low compression force.
Journal ArticleDOI
Polymeric films as a promising carrier for bioadhesive drug delivery: Development, characterization and optimization.
Pallavi Bassi,Gurpreet Kaur +1 more
TL;DR: The optimized film showed appropriate anti candida activity through appearance of zone of inhibition during antifungal activity testing study and showed best fit to Korsmeyer–Peppas model with R2 of 0.9990 and the release mechanism to be super case-II.
Journal ArticleDOI
Preparation and characterization of poly(ε-caprolactone) nanospheres containing the local anesthetic lidocaine
Estefânia Vangelie Ramos Campos,Nathalie Ferreira Silva de Melo,Nathalie Ferreira Silva de Melo,Viviane A. Guilherme,Eneida de Paula,André Henrique Rosa,Daniele Ribeiro de Araujo,Daniele Ribeiro de Araujo,Leonardo Fernandes Fraceto,Leonardo Fernandes Fraceto +9 more
TL;DR: Cytotoxicity and pharmacological tests confirmed that association with the NSs reduced the toxicity of LDC, and prolonged its anesthetic action, which could potentially be used in applications requiring gradual anesthetic release, especially dental procedures.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.