Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
Citations
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Journal ArticleDOI
In vitro dissolution similarity factor (f2) and in vivo bioequivalence criteria, how and when do they match? Using a BCS class II drug as a simulation example.
Feifan Xie,Shan Ji,Zeneng Cheng +2 more
TL;DR: The results indicate that the public standard for in vitro dissolution f2 similarity criterion (f2⩾50) is probably slightly conservative and may be widened to an appropriate lower critical value.
Journal ArticleDOI
Drug release from ordered mesoporous silicas.
TL;DR: The state-of-the-art in the investigation of drugs release from Silica-based ordered Mesoporous Materials (SMMs) is reviewed and the new approaches under investigation including the design of smart stimuli-responsive materials and other recent proposals for a future investigation are mentioned.
Journal ArticleDOI
Promising dissolution enhancement effect of soluplus on crystallized celecoxib obtained through antisolvent precipitation and high pressure homogenization techniques.
Alireza Homayouni,Fatemeh Sadeghi,Jaleh Varshosaz,Hadi Afrasiabi Garekani,Ali Nokhodchi,Ali Nokhodchi +5 more
TL;DR: The results showed that celecoxib nanoparticle can be obtained when soluplus was added to the crystallization medium, and DSC and XRPD proved that samples obtained via HPH technique are more crystalline than the samples obtained through only antisolvent crystallization technique.
Journal ArticleDOI
Silk fibroin-based complex particles with bioactive encrustation for bone morphogenetic protein 2 delivery
Pujiang Shi,Sunny Akogwu Abbah,Sunny Akogwu Abbah,Kushagra Saran,Yong Zhang,Jun Li,Hee-Kit Wong,James C.H. Goh +7 more
TL;DR: The particles show high efficacies of BMP-2 delivery, and introduction of the complex particle can progressively enhance osteogenesis, which is evident in the high ALP enzyme activity as well as the increased level of expression of osteogenic genes.
Journal ArticleDOI
In vivo and in vitro evaluation of the use of a newly developed melatonin loaded emulsion combined with UV filters as a protective agent against skin irradiation
Ana Sierra,María Luisa del Carmen Garduño Ramírez,Ana Cristina Calpena Campmany,Adolfina Ruiz Martinez,Beatriz Clares Naveros +4 more
TL;DR: MMIX formulation would be a promising formulation for preventing the undesirable adverse effects of UV skin irradiation because melatonin not only acts as a potent antioxidant itself, but also is capable of activating an endogenous enzymatic protective system against oxidative stress.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.