Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
Citations
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Journal ArticleDOI
The use of FT-IR imaging as an analytical tool for the characterization of drug delivery systems.
TL;DR: In this study, the delivery characteristics of the drug, testosterone, suspended in a poly(ethylene oxide) (PEO) matrix was observed usingFT-IR imaging spectroscopy, revealing changes in concentration and polymer orientation as well as inter-species interactions.
Journal ArticleDOI
L-Trp adsorption into silica mesoporous materials to promote bone formation.
TL;DR: The control of the L-Trp release is the first step in controlled and localized protein delivery technologies, and opens novel perspectives for designing bioactive silica-based devices suitable for bone-healing applications.
Journal ArticleDOI
Franz Diffusion Cell Approach for Pre-Formulation Characterisation of Ketoprofen Semi-Solid Dosage Forms.
Constain H. Salamanca,Alvaro Barrera-Ocampo,Juan C Lasso,Nathalia Camacho,Cristhian J. Yarce +4 more
TL;DR: The KTP permeation profiles demonstrated that depending on the membrane type and the vehicle used, the permeation is strongly affected, and high permeation efficiencies were obtained for the gel formulation, and the opposite effect was observed for the suspension formulation.
Journal ArticleDOI
Optimization of nanostructured lipid carriers of lamotrigine for brain delivery: in vitro characterization and in vivo efficacy in epilepsy.
TL;DR: It is concluded that IN administration of LMT NLCs in rats is able to maintain higher brain concentration of L MT compared to IN and oral drug solution.
Journal ArticleDOI
Preparation of starch nanoparticles loaded with quercetin using nanoprecipitation technique.
Yousof Farrag,Walther Ide,Belén Montero,Maite Rico,Saddys Rodríguez-Llamazares,Luis Barral,Rebeca Bouza +6 more
TL;DR: The starch-quercetin nanoparticles from cereal origin showed the lowest loading percentage and the lowest fraction released of quercetIn in comparison with nanoparticlesFrom tuber and legume origin and the release kinetics seem to be controlled mainly by Fickian diffusion.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.