Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
Citations
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Journal ArticleDOI
Bone-regenerative bioceramic implants with drug and protein controlled delivery capability
TL;DR: The influence of several host matrix parameters (pore size, surface area, symmetry and surface modification) in drug hosting and controlled delivery is deeply revised and mesoporous systems are investigated as protein delivery systems using Bovine Serum Albumin as protein model.
Journal ArticleDOI
Design of controlled release systems for THEDES—Therapeutic deep eutectic solvents, using supercritical fluid technology
Ivo Manuel Ascensão Aroso,Rita Craveiro,Ângelo Rocha,Madalena Dionísio,Susana Barreiros,Rui L. Reis,Alexandre Paiva,Ana Rita C. Duarte +7 more
TL;DR: A therapeutic DES based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC), providing important clues for the development of carriers for the sustainable delivery of bioactive compounds.
Journal ArticleDOI
Extract from Lycium ruthenicum Murr. Incorporating κ-carrageenan colorimetric film with a wide pH–sensing range for food freshness monitoring
Jingrong Liu,Hualin Wang,Min Guo,Linlin Li,Minmin Chen,Suwei Jiang,Xingjiang Li,Shaotong Jiang +7 more
TL;DR: In this paper, a wide pH-sensing colorimetric film of κ-carrageenan incorporated with extract from Lycium ruthenicum Murr (Car-LRM) was designed for food freshness monitoring.
Journal ArticleDOI
Mathematical modeling and in vitro study of controlled drug release via a highly swellable and dissoluble polymer matrix: polyethylene oxide with high molecular weights.
TL;DR: The overall drug release process is found to be highly dependent on the matrix swelling, drug and water diffusion, polymer dissolution and initial dimensions of the tablets, and predicts with a very good agreement with experimental data at different initial loadings.
Journal ArticleDOI
Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil.
Ana Maria Sierra Villar,Beatriz Clares Naveros,Ana Cristina Calpena Campmany,Monserrat Aróztegui Trenchs,Coloma Barbé Rocabert,Lyda Halbaut Bellowa +5 more
TL;DR: An overview of the SNEDDS of the gemfibrozil as a promising alternative to improve oral absorption is provided and amodelistic parameters were calculated being the dissolution efficiency significantly higher forSNEDDS, confirming that the developed SNED DS formulation was superior to commercial formulation with respect to in vitro dissolution profile.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.