Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
Citations
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Journal ArticleDOI
Design and evaluation of lipoprotein resembling curcumin-encapsulated protein-free nanostructured lipid carrier for brain targeting
Fanfei Meng,Sajid Asghar,Yurui Xu,Jianping Wang,Xin Jin,Wang Zhilin,Jing Wang,Qineng Ping,Jianping Zhou,Yanyu Xiao +9 more
TL;DR: The considerable in vitro and in vivo performance of the safe and biocompatible PS80-NLC makes it a suitable option for further investigations in brain targeted drug delivery.
Journal ArticleDOI
Effect of micropatterning induced surface hydrophobicity on drug release from electrospun cellulose acetate nanofibers
Shivakalyani Adepu,Mrunalini K. Gaydhane,Manohar Kakunuri,Chandra Shekhar Sharma,Mudrika Khandelwal,Stephen J. Eichhorn +5 more
TL;DR: Results show that with optimized micro- patterned dimensions, a zero order sustained drug release of up to 12 h may be achieved for the transdermal system when compared to non-patterned samples.
Journal ArticleDOI
Enhanced antibacterial activity of Egyptian local insects' chitosan-based nanoparticles loaded with ciprofloxacin-HCl
TL;DR: Chitosan-based nanoparticles (CSNPs) showed countless interest as polymeric drug delivery system (DDS) with its improved bioavailability, and stability when compared with traditional DDS, and characterized using particle size distribution, zeta potential, and drug entrapment efficiency.
Journal ArticleDOI
A Novel Approach for Analyzing the Dissolution Mechanism of Solid Dispersions
TL;DR: The chemical-potential-gradient model combined with PC-SAFT can be used to analyze the dissolution mechanism of solid dispersions and to describe and predict the dissolution profiles of API as function of stirring speed, temperature and pH value of the medium.
Journal ArticleDOI
Enhancement of dissolution rate of class II drugs (Hydrochlorothiazide); a comparative study of the two novel approaches; solid dispersion and liqui-solid techniques.
TL;DR: Liqui-solid technique and solid dispersion formation are two novel approaches for enhancement of dissolution rate of BCS class II drugs and results obtained indicated that liqui- solid compact formulations were more effective in enhancing the dissolution rate compared withSolid dispersion technique.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.