Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
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An Integrated Microrobotic Platform for On-Demand, Targeted Therapeutic Interventions
Stefano Fusco,Mahmut Selman Sakar,Stephen Kennedy,Christian Peters,Rocco Bottani,Fabian H. L. Starsich,Angelo S. Mao,Georgios A. Sotiriou,Salvador Pané,Sotiris E. Pratsinis,David J. Mooney,Bradley J. Nelson +11 more
TL;DR: The presented microrobotic platform combines together the advantages of self-folding NIR light sensitive polymer bilayers, magnetic alginate microbeads, and a 3D manipulation system, to propose a solution for targeted, on-demand drug and cell delivery.
Journal ArticleDOI
Electrospun polyvinyl-alcohol nanofibers as oral fast-dissolving delivery system of caffeine and riboflavin
TL;DR: Electrospun nanofibers prepared from electrospinning PVA/drug aqueous solutions possessed an ultrafine morphology with an average diameter in the range of 260-370 nm, indicating that drugs can be released in a burst manner.
Journal ArticleDOI
Targeted delivery of tacrine into the brain with polysorbate 80-coated poly(n-butylcyanoacrylate) nanoparticles.
Barnabas Wilson,Malay K. Samanta,Kumaraswamy Santhi,Kokilampal Perumal Sampath Kumar,N. Paramakrishnan,B Suresh +5 more
TL;DR: It is demonstrated that the brain concentration of intravenously injected tacrine can be enhanced by binding to poly(n-butylcyanoacrylate) nanoparticles, coated with 1% the nonionic surfactant polysorbate 80.
Journal ArticleDOI
PLGA Nanoparticles for Oral Delivery of Hydrophobic Drugs: Influence of Organic Solvent on Nanoparticle Formation and Release Behavior In Vitro and In Vivo Using Estradiol as a Model Drug
TL;DR: The aim of present investigation was to screen different solvents for optimizing nanoparticle preparation in terms of particle size, entrapment efficiency, and finally, release behavior using a model drug estradiol to suggest that particle size has significant role in determining the fate of nanoparticles in vivo.
Journal ArticleDOI
Paraquat-loaded alginate/chitosan nanoparticles: preparation, characterization and soil sorption studies.
Mariana dos Santos Silva,Daniela Sgarbi Cocenza,Renato Grillo,Renato Grillo,Nathalie Ferreira Silva de Melo,Nathalie Ferreira Silva de Melo,Paulo Sergio Tonello,Luciana Camargo de Oliveira,Douglas Lopes Cassimiro,André Henrique Rosa,Leonardo Fernandes Fraceto,Leonardo Fernandes Fraceto +11 more
TL;DR: The results presented in this work show that association of paraquat with alginate/chitosan nanoparticles alters the release profile of the herbicide, as well as its interaction with the soil, indicating that this system could be an effective means of reducing negative impacts caused by paraquats.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.