Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
Citations
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Stability study of full-length antibody (anti-TNF alpha) loaded PLGA microspheres.
Sarah Marquette,Sarah Marquette,Claude Peerboom,Andrew Yates,Laurence Denis,Ingrid Langer,Karim Amighi,Jonathan Goole +7 more
TL;DR: It was demonstrated that the MAb loaded PLGA microspheres were stable when stored at 5 ± 3°C and that the Resomer(®) RG755S, composed of 75%(w/w) lactic acid as PLGA, was preferred to preserve the stability of the system.
Journal ArticleDOI
Improved Chemical Stability and Antiproliferative Activities of Curcumin-Loaded Nanoparticles with a Chitosan Chlorogenic Acid Conjugate.
TL;DR: The results suggest that CS-CA-based nanoparticles are promising candidates for the encapsulation and controlled release of hydrophobic, bioactive compounds and can improve these compounds' chemical stabilities and anticancer activities.
Journal ArticleDOI
Tuning Crystal Structures of Iron-Based Metal–Organic Frameworks for Drug Delivery Applications
Hao Pham,Kimberly Ramos,Andy Sua,Jessica Acuna,Katarzyna Slowinska,Travis Nguyen,Angela Bui,Mark D. R. Weber,Fangyuan Tian +8 more
TL;DR: The very low toxicity and controlled drug release behavior of Fe-MIL-88B suggest that better materials for drug-delivery applications can be created by controlling not only the composition but also the crystal structure and nanoparticle morphology of the material.
Journal ArticleDOI
Probabilistic models for drug dissolution. Part 1. Review of Monte Carlo and stochastic cellular automata approaches
TL;DR: In this article, Monte Carlo (MC) techniques have been used in simulating various complex systems, such as drug dissolution and drug delivery, and their applications in the field of drug delivery.
Journal ArticleDOI
A Concept in Bactericidal Materials: The Entrapment of Chlorhexidine within Silver
TL;DR: In this paper, the entrapment of an organic biocidal agent within a bactericidal metal, which leads to synergism between the two components, was demonstrated for the entrapping of chlorhexidine digluconate (CHD) within an aggregated silver matrix, forming the CHD@silver composite.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.