Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
Citations
More filters
Journal ArticleDOI
Mathematical modeling and simulation of drug release from microspheres: Implications to drug delivery systems
TL;DR: This article aims to provide a comprehensive review of existing mathematical models and simulations of drug release from polymeric microspheres and of drug transport in adjacent tissues and to evaluate the application of existing models to nanoscale drug delivery systems specifically for hydrophobic and hydrophilic molecules.
Journal ArticleDOI
Potential scenarios for nanomaterial release and subsequent alteration in the environment
Bernd Nowack,James F. Ranville,Stephen A. Diamond,Julian A. Gallego-Urrea,Chris D. Metcalfe,Jérôme Rose,Nina Horne,Albert A. Koelmans,Stephen J. Klaine +8 more
TL;DR: It is not possible to assess the risks associated with the use of ENM by investigating only the pristine form of the ENM, without considering alterations and transformation processes, and a more definitive classification scheme for ENM should be adopted.
Journal ArticleDOI
Estradiol loaded PLGA nanoparticles for oral administration: effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo.
TL;DR: The results indicate that nanoparticulate formulations are ideal carriers for oral administration of estradiol having great potential to address the dose related issues of Estradiol.
Journal ArticleDOI
Confinement and Controlled Release of Bisphosphonates on Ordered Mesoporous Silica-Based Materials
TL;DR: The bisphosphonate adsorption rate has been increased from 1% in oral administration to around 40% locally delivered, and the use of these drug delivery systems opens new fields with new possibilities for tissue engineering.
Journal ArticleDOI
Rationale of Drug Encapsulation and Release from Biocompatible Porous Metal−Organic Frameworks
Denise Cunha,Mouna Ben Yahia,Mouna Ben Yahia,Shaun Hall,Stuart R. Miller,Hubert Chevreau,Erik Elkaim,Guillaume Maurin,Patricia Horcajada,Christian Serre +9 more
TL;DR: In this article, a joint experimental and computational systematic exploration of the driving forces that govern encapsulation of active ingredients (solvent, starting material dehydration, drug/material ratio, immersion time, and several consecutive impregnations) and its kinetics of delivery (structure, polarity,...) was performed using a series of porous biocompatible metal-organic frameworks (MOFs) that bear different topologies, connectivities, and chemical compositions.
References
More filters
Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.