Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
Citations
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Journal ArticleDOI
The kinetic study of isotretinoin release from nanoemulsion
TL;DR: In this article, a nanoemulsion formulation was developed as a carrier for topical delivery of isotretinoin and determined the release kinetic of the active from the nano-emulsion.
Journal Article
Preparation and characterization of estradiol-loaded PLGA nanoparticles using homogenization-solvent diffusion method
TL;DR: According to the size and surface properties of the prepared particles, it may be concluded that they are a good formulation for non-parenteral routes of administration.
Journal ArticleDOI
Formulation, functional evaluation and ex vivo performance of thermoresponsive soluble gels - A platform for therapeutic delivery to mucosal sinus tissue.
TL;DR: The lead poloxamer‐based soluble gels displayed extended drug release profiles in conditions mimicking the human nasal cavity, which indicates their suitability for treating a range of conditions affecting the nasal cavity/sinuses.
Journal ArticleDOI
Gastroretentive extended release of metformin from methacrylamide-g-gellan and tamarind seed gum composite matrix
Rosy Priyadarshini,Gouranga Nandi,Abhijit Changder,Sailee Chowdhury,Sudipta Chakraborty,Lakshmi Kanta Ghosh +5 more
TL;DR: Kinetic modeling unveiled anomalous non-Fickian transport based drug release mechanism and the optimized formulation showed excellent buoyancy over a 10h period with buoyancy lag time and significant mucoadhesion and drug release over a period of 10h with f2=71.58.
Journal ArticleDOI
Investigation of the in vitro performance difference of drug-Soluplus® and drug-PEG 6000 dispersions when prepared using spray drying or lyophilization.
TL;DR: Evaluating the physicochemical and in vitro characteristics of solid dispersions using BCS II model drugs with Soluplus and one of its component homopolymers, PEG 6000 found no crystalline material exists in the dispersions, suggesting that the drug is amorphous or molecularly dispersed.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.