Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
Citations
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Journal ArticleDOI
Release kinetics of paclitaxel and cisplatin from two and three layered gold nanoparticles.
TL;DR: It is concluded that functionalization of gold nanoparticles with a combination of TL and PC may help to modulate both hydrophilic and hydrophobic drug release kinetics, while the addition of HDL may enhance long term release of hydrophobia drug.
Journal ArticleDOI
Facile Preparation of Poly(lactic acid)/Brushite Bilayer Coating on Biodegradable Magnesium Alloys with Multiple Functionalities for Orthopedic Application
Lei Zhang,Jia Pei,Haodong Wang,Yongjuan Shi,Jialin Niu,Feng Yuan,Hua Huang,Hua Zhang,Guangyin Yuan +8 more
TL;DR: It is suggested that the bilayer poly( lactic acid)/brushite coating provided effective protection for Mg alloy, greatly enhanced cytocompatibility and bioactivity, and, moreover, possessed local drug delivery capability; hence magnesium alloy with poly(lactic acid) / brushite coating presents great potential in orthopedic clinical applications, especially for localized bone therapy.
Journal ArticleDOI
In Vitro Release Study of the Polymeric Drug Nanoparticles: Development and Validation of a Novel Method.
TL;DR: A novel sample and separate (SS) method by combining the United States Pharmacopeia (USP) apparatus II (paddle) with well-validated centrifugal ultrafiltration (CU) technique that efficiently separated the free drug from nanoparticles.
Journal ArticleDOI
Antimicrobial Activity and Cytotoxicity to Tumor Cells of Nitric Oxide Donor and Silver Nanoparticles Containing PVA/PEG Films for Topical Applications.
Wallace R. Rolim,Joana C. Pieretti,Débora L. Renó,Bruna de Araujo Lima,Mônica H. M. Nascimento,Felipe Nogueira Ambrosio,Christiane Bertachini Lombello,Marcelo Brocchi,Ana Carolina Santos de Souza,Amedea B. Seabra +9 more
TL;DR: This is the first report to describe the preparation of PVA/PEG solid films containing GSNO and/or biogenically synthesized AgNPs, which might find important biomedical applications as a solid material with antimicrobial and antitumorigenic properties.
Journal ArticleDOI
Microcrystalline cellulose, a useful alternative for sucrose as a matrix former during freeze-drying of drug nanosuspensions - a case study with itraconazole.
Bernard Van Eerdenbrugh,Sofie Vercruysse,Johan A. Martens,Jan Vermant,Ludo Froyen,Jan Van Humbeeck,Guy Van den Mooter,Patrick Augustijns +7 more
TL;DR: As the fraction showing burst dissolution increased with higher MCC content, the system holds promise to maintain the dissolution enhancing properties of nanoparticles in the dry form.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.