Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
Citations
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Journal ArticleDOI
Metal-organic frameworks as efficient materials for drug delivery.
Patricia Horcajada,Christian Serre,María Vallet-Regí,Muriel Sebban,Francis Taulelle,Gérard Férey,Gérard Férey +6 more
Journal ArticleDOI
Flexible Porous Metal-Organic Frameworks for a Controlled Drug Delivery
Patricia Horcajada,Christian Serre,Guillaume Maurin,Naseem A. Ramsahye,Francisco Balas,María Vallet-Regí,Muriel Sebban,Francis Taulelle,Gérard Férey +8 more
TL;DR: In each case, the very slow and complete delivery of Ibuprofen was achieved under physiological conditions after 3 weeks with a predictable zero-order kinetics, which highlights the unique properties of flexible hybrid solids for adapting their pore opening to optimize the drug-matrix interactions.
Journal ArticleDOI
DDSolver: An Add-In Program for Modeling and Comparison of Drug Dissolution Profiles
TL;DR: The development of a software program, called DDSolver, for facilitating the assessment of similarity between drug dissolution data and to establish a model library for fitting dissolution data using a nonlinear optimization method is described.
Journal ArticleDOI
Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability
Prakash Khadka,Jieun Ro,Hyeongmin Kim,Iksoo Kim,Jeong Tae Kim,Hyun-Il Kim,Jae Min Cho,Gyiae Yun,Jaehwi Lee +8 more
TL;DR: A review of solid particle technologies available for improving solubility, dissolution, and bioavailability of drugs with poor aqueous solubilities is presented in this article, where the authors highlight the solid particle technology available to improve the bioavailability.
Journal ArticleDOI
On the use of the Weibull function for the discernment of drug release mechanisms.
TL;DR: The entire drug release kinetics of various published data and experimental data from commercial or prepared controlled release formulations of diltiazem and diclofenac are analyzed using the Weibull function to determine the mechanism of transport of a drug through the polymer matrix.
References
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Journal ArticleDOI
Zero-order release from biphasic polymer hydrogels
TL;DR: This is the first controlled release study performed using a new material, namely, biphasic polymer hydrogels, and mathematical models of different mechanisms of release from two-phase networks were developed to explain the observed profiles.
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Evaluation and comparison of dissolution data derived from different modified release dosage forms: an alternative method.
Viness Pillay,Reza Fassihi +1 more
TL;DR: Investigation of the effect of delivery system positioning in accordance with the USP 23-recommended dissolution methods and the proposed modification on drug release from controlled release systems having different operating release mechanisms found that in the case of the swellable sticking systems full surface exposure to the dissolution medium results in greater release rate.
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Application of binary polymer system in drug release rate modulation. 2. Influence of formulation variables and hydrodynamic conditions on release kinetics
Hyunjo Kim,Reza Fassihi +1 more
TL;DR: It is shown that hydrodynamic stress and intensity of fluid flow causes greater attrition at the swollen periphery and is responsible for dramatic increases in release rates, confirming that the mechanism of drug release from this swellable hydrophilic delivery system is erosion dependent.
Journal ArticleDOI
Investigation of Factors Influencing Release of Solid Drug Dispersed in Inert Matrices III: Quantitative Studies Involving the Polyethylene Plastic Matrix
TL;DR: A direct correlation between surfactant activity and the rate of release has been found and it is proposed that these findings are consistent with an “encapsulated” drug particle model.
Journal ArticleDOI
In vitro release modulation from crosslinked pellets for site-specific drug delivery to the gastrointestinal tract. I. Comparison of pH-responsive drug release and associated kinetics
Viness Pillay,Reza Fassihi +1 more
TL;DR: It is concluded that the proper selection of rate-controlling polymers and their interactive potential for crosslinking is important, and will determine the overall size and shape of pellets, the duration and pattern of dissolution profiles, pH sensitivity, drug loading capacity and mechanism of drug release.