Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
Citations
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Journal ArticleDOI
Low temperature extruded implants based on novel hydrophilic multiblock copolymer for long-term protein delivery.
Milica Stanković,Hans de Waard,Rob Steendam,Christine Hiemstra,Johan Zuidema,Henderik W. Frijlink,Wouter L. J. Hinrichs +6 more
TL;DR: This hydrophilic multiblock copolymer has promising characteristics for the preparation by melt extrusion of protein delivery implants with a release profile that is sustained over a period of more than 7 months.
Journal ArticleDOI
Polyion complex hydrogels from chemically modified cellulose nanofibrils: Structure-function relationship and potential for controlled and pH-responsive release of doxorubicin.
TL;DR: The first time that polyion complex formation between complementarily-modified cellulose nanofibrils containing complementary charges has been reported, and the results may lead to new ideas on applications of the very promising nanocellulosic materials.
Journal ArticleDOI
In-vitro investigation and hydrolytic degradation of antibacterial nanocomposites based on PLLA/triclosan/nano-hydroxyapatite
TL;DR: In this paper, nano hydroxyapatite (nHA) nanoparticles were added to the triclosan nanoparticles to improve the properties of the nanocomposite.
Journal ArticleDOI
Poly(ε-caprolactone) nanocapsules carrying the herbicide atrazine: effect of chitosan-coating agent on physico-chemical stability and herbicide release profile
TL;DR: In this article, the effect of coating the nanocapsule surfaces using different concentrations of chitosan was evaluated, and the results indicated that their association with coated modified release carrier systems could be beneficial from both ecological and economic perspectives.
Journal ArticleDOI
Preparation and characterization of spray-dried powders intended for pulmonary delivery of insulin with regard to the selection of excipients.
TL;DR: Of the formulations studied, the third, containing mannitol/sodium alginate/insulin/s sodium citrate showed promising characteristics, optimal for systemic delivery of proteins via deep lung deposition.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.