Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
Citations
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Journal ArticleDOI
Miconazole-loaded nanostructured lipid carriers (NLC) for local delivery to the oral mucosa: improving antifungal activity.
Alves Mendes,Ana Catarina Silva,José A. M. Catita,Fátima Cerqueira,Carla Gabriel,Carla Martins Lopes +5 more
TL;DR: It was demonstrated that the encapsulation of miconazole in NLC allows for obtaining the same therapeutic effect of a commercial oral gel formulation, using a 17-fold lower dose of miconsazole.
Journal ArticleDOI
Perspectives on the role of nanotechnology in bone tissue engineering
TL;DR: This review surveys new developments in bone tissue engineering, specifically focusing on the promising role of nanotechnology and describes future avenues of research to enable a new generation of bone scaffolds that will surpass the performance of autologous bone implants.
Journal ArticleDOI
Controlled release system for ametryn using polymer microspheres: preparation, characterization and release kinetics in water.
Renato Grillo,Anderson do Espirito Santo Pereira,Nathalie Ferreira Silva de Melo,Nathalie Ferreira Silva de Melo,Raquel Martins Porto,L. O. Feitosa,Paulo Sergio Tonello,Newton Luiz Dias Filho,André Henrique Rosa,Renata de Lima,Leonardo Fernandes Fraceto,Leonardo Fernandes Fraceto +11 more
TL;DR: Results presented in this paper are promising, in view of the successful encapsulation of ametryn in PHB or PHBV polymer microparticles, and indications that this system may help reduce the impacts caused by the herbicide, making it an environmentally safer alternative.
Journal ArticleDOI
Analysis of dissolution data using modified versions of Noyes-Whitney equation and the Weibull function.
TL;DR: In this article, the authors developed modified, branched versions of the Noyes-Whitney and the Weibull equations, including explicitly the solubility/dose parameter, for the analysis of dissolution data, which reach the plateau either at infinite or finite time.
Journal ArticleDOI
The chronic toxicity of ZnO nanoparticles and ZnCl2 to Daphnia magna and the use of different methods to assess nanoparticle aggregation and dissolution.
Nathalie Adam,Claudia Schmitt,Josep Galceran,Encarna Companys,Alexander Vakurov,Rachel Wallace,Dries Knapen,Ronny Blust +7 more
TL;DR: It can be concluded that the toxicological effects of ZnO nanoparticles at the chronic level can be largely attributed to the dissolved fraction rather than the nanoparticles or initially formed aggregates.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.