Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
Citations
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Journal ArticleDOI
Montmorillonite nanodevices for the colon metronidazole delivery.
Ilaria Calabrese,Gennara Cavallaro,Cinzia Scialabba,Mariano Licciardi,Marcello Merli,Luciana Sciascia,Maria Liria Turco Liveri +6 more
TL;DR: The investigation of the release profiles and the comparison with the commercial formulation of the drug reveal that the new-tailor made formulation could be fruitful exploited for successfully prolonged the action of drug in the desired site.
Journal ArticleDOI
Rheological behavior and microstructure of release-controlled hydrogels based on xanthan gum crosslinked with sodium trimetaphosphate
TL;DR: In this article, the transition from hydrogen bonding to chemical crosslinking for the xanthan gum (XG) chains occurred and reached a balance approximately at 25 and 37°C, respectively.
Journal ArticleDOI
Cellulose, chitosan, and keratin composite materials. Controlled drug release.
TL;DR: The results clearly indicate that drug release can be controlled and adjusted at any rate by judiciously selecting the concentration of KER in the composites, and indicates that this novel composite can be used in ways which hitherto were not possible, e.g., as a high-performance bandage to treat chronic and ulcerous wounds.
Journal ArticleDOI
Loading and release of 5-fluorouracil from HY zeolites with varying SiO2/Al2O3 ratios
TL;DR: The 5-fluorourouracil content in the zeolites was approximately 90-110mg/g as determined by thermogravimetric analysis as mentioned in this paper, which indicated that the aluminum content was critical in determining the extent of release.
Journal ArticleDOI
Influence of different structured channels of mesoporous silicate on the controlled ibuprofen delivery
TL;DR: In this article, the influence of mesoporous structure on drug delivery property was investigated using 3-(2-aminoethylamino) propyltrimethoxysilane as ibuprofen carrier and modified SBA-15 with relative large and long ordered mesopores.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.