Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
Citations
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Biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment
Gaizhen Kuang,Zhiyun Zhang,Zhiyun Zhang,Shi Liu,Dongfang Zhou,Xiaolan Lu,Xiabin Jing,Yubin Huang +7 more
TL;DR: In vivo antitumor and safety studies demonstrated that PEO10-PLA90 fibers can achieve optimized local cancer treatment efficacy and avoid undesired adverse reactions.
Journal ArticleDOI
Development of PCL/PEO electrospun fibrous membranes blended with silane-modified halloysite nanotube as a curcumin release system
TL;DR: In this paper, electrospun fibrous membranes based on polycaprolactone (PCL)/polyethylene oxide (PEO) blended with pure, 3-Aminopropyltriethoxysilane (APTES) or 3-Glycidoxypropyltrimethoxylynne (GPTMS) modified halloysite nanotubes (HNT) were prepared by electrospinning for curcumin (Cur) delivery system.
Journal ArticleDOI
Controlling the drug release rate from biocompatible polymers with micro-patterned diamond-like carbon (DLC) coating
K. Enomoto,Terumitsu Hasebe,Terumitsu Hasebe,R. Asakawa,Aki Kamijo,Yukihiro Yoshimoto,Tetsuya Suzuki,Koji Takahashi,Atsushi Hotta +8 more
TL;DR: It was found that the drug eluting profiles could be effectively controlled by changing the cover area of micro-patterned DLC coatings on polymers, which may be applicable to the next-generation DES system that eventually prevents late thrombosis.
Journal ArticleDOI
Deproteinized Natural Rubber Latex/Hydroxypropylmethyl Cellulose Blending Polymers for Nicotine Matrix Films
Wiwat Pichayakorn,Jirapornchai Suksaeree,Prapaporn Boonme,Thanaporn Amnuaikit,Wirach Taweepreda,Garnpimol C. Ritthidej +5 more
TL;DR: Nicotine matrix films were prepared using DNRL/HPMC blends for transdermal delivery as mentioned in this paper, and the compatibility of each ingredient in the blended films was confirmed by FT-IR, XRD, and DSC.
Journal ArticleDOI
Influence of excipients on solubility and dissolution of pharmaceuticals
TL;DR: It was found that the solubility of indomethacin and naproxen was increased with an addition of the selected excipients, which was also predicted by the perturbed-chain statistical associating fluid theory (PC-SAFT), and the dissolution rate of the API was decreased in some cases.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.