Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
Citations
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Facile preparation of UiO-66 nanoparticles with tunable sizes in a continuous flow microreactor and its application in drug delivery
TL;DR: In this paper, UiO-66 nanoparticles have been facilely prepared in a continuous flow microreactor, in which the particle size can be tuned from hundreds to dozens of nanometers by controlling of the residence time.
Journal ArticleDOI
Polyethylene/paraffin binary composites for phase change material energy storage in building: A morphology, thermal properties, and paraffin leakage study
Fang Chen,Michael P. Wolcott +1 more
TL;DR: In this paper, paraffin was used as a phase change material (PCM) and three types polyethylene (PE) were used as the structural matrix to investigate the morphology of PE/paraffin blends and evaluate the influence on blend behavior.
Journal ArticleDOI
Dissolution process analysis using model-free Noyes-Whitney integral equation.
TL;DR: In this study, Noyes-Whitney integral equation was proposed and applied to represent the drug dissolution profiles of a solid formulation via the non-linear least squares (NLLS) method, and thereby the rate constant and specific surface area could be obtained by NLLS method.
Journal ArticleDOI
Paclitaxel-loaded PCL-TPGS nanoparticles: in vitro and in vivo performance compared with Abraxane®.
Ezequiel Bernabeu,Gustavo Helguera,Maria J. Legaspi,Lorena Gonzalez,Christian Höcht,Carlos A. Taira,Diego A. Chiappetta +6 more
TL;DR: In vivo studies demonstrated that PTX-loaded PCL-TPGS NPs exhibited longer systemic circulation time and slower plasma elimination rate than Taxol(®) and Abraxane(®).
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KinetDS: An Open Source Software for Dissolution Test Data Analysis
Aleksander Mendyk,Renata Jachowicz,Kamil Fijorek,Przemysław Dorożyński,Piotr Kulinowski,Sebastian Polak +5 more
TL;DR: The in vitro dissolution test is a standard tool for characterization of manufactured products and results of the dissolution test must be expressed in mathematical terms; this is realized by fitting various models to the cumulative dissolution curves.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.