Journal ArticleDOI
Modeling and comparison of dissolution profiles.
TLDR
Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2001-05-01. It has received 4794 citations till now. The article focuses on the topics: Dissolution testing & Dosage form.read more
Citations
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Journal ArticleDOI
Microencapsulation of Mentha spicata essential oil by spray drying: Optimization, characterization, release kinetics of essential oil from microcapsules in food models
TL;DR: In this article, the authors optimize microencapsulation conditions of spearmint essential oil (SEO) by spray drying, using a blend of inulin and gum Arabic as wall material The optimal conditions were (35 % solid wall, 4% essential oil concentration, and 110°C inlet temperature) with maximum oil retention 910 % Differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) were confirmed that SEO was encapsulated without any chemical interaction Release study of produced powder at the optimized process conditions was evaluated
Journal ArticleDOI
Hydrodynamic, mass transfer, and dissolution effects induced by tablet location during dissolution testing
Ge Bai,Piero M. Armenante +1 more
TL;DR: The proposed CFD-based model can satisfactorily predict the mass transfer coefficients and dissolution profiles for non-disintegrating tablets and predicts mass transfer rates that correlate well with the experimental ones.
Journal ArticleDOI
Exploiting gelatin nanocarriers in the pulmonary delivery of methotrexate for lung cancer therapy.
TL;DR: Results showed that Box Behnken design was able to optimize preparation parameters to yield uniform nanoparticles with suitable particle size for cancer cells uptake, providing a promising platform for lung cancer therapy.
Journal ArticleDOI
Formulation and optimization of itraconazole polymeric lipid hybrid nanoparticles (Lipomer) using Box Behnken design.
TL;DR: The tunable particle size, surface charge, and favourable encapsulation efficiency with a sustained drug release profile of PLHNs suggesting that it could be promising system envisioned to increase the bioavailability by improving intestinal permeability through lymphatic uptake, M cell of payer’s patch or paracellular pathway.
Journal ArticleDOI
Preparation, characterization, and in vivo anti-ulcer evaluation of pantoprazole-loaded microparticles.
TL;DR: In vivo anti-ulcer evaluation showed that the microparticles were able to protect rat stomachs against ulcer formation, while the drug aqueous solution did not present activity.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this article, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.
Journal ArticleDOI
Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.