Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Resveratrol alone and its Combination with Pterostilbene amends Valproic Acid-Induced Autism in Swiss Albino Mice: Postnatal Model
TL;DR: In this paper, the therapeutic role of resveratrol and pterostilbene alone and combination in reversing the behavioral, biochemical, and histopathological alterations in valproic acid (VPA) induced oxidative stress and neuron damage in a postnatal model of autism.
Journal Article
Neuroprotective Role of Glutathione against Hydrogen Peroxide Induced Toxicity to the Neuronal Cells in Culture
TL;DR: Evidence that glutathione may act as a significantly bioactive compound is provided and the possibility that it may be important in health and disease, and for protection against DNA damage by oxidative stress is supported.
Journal ArticleDOI
Role of melatonin in autism spectrum disorders in a male murine transgenic model: Study in the prefrontal cortex
TL;DR: In this article , the beneficial effect induced by melatonin administration and its possible mechanism of action in a transgenic mouse model of autism, immediately after weaning, was analyzed and the results show that melatonin may be a possible adjuvant therapeutic strategy in ASDs.
Posted ContentDOI
SOX7: Novel Autistic Gene Identified by Analysis of Multi-Omics Data
TL;DR: Wang et al. as mentioned in this paper performed gene-based association studies with adaptive test using genome-wide association studies (GWAS) summary statistics with two large GWAS datasets (ASD 2019 data: 18,382 ASD cases and 27,969 controls [discovery data]; ASD 2017 data: 6,197 cases and 7,377 controls [replication data]) which were obtained from the Psychiatric Genomics Consortium (PGC).
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?