Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Book ChapterDOI
16 Cytokine Polymorphisms in Autism: Their Role in Immune Alterations
Fabian A Crespo,Rafael Fernandez-Botran,Christopher R. Tillquist,Lonnie Sears,Meghan Mott,Manuel F. Casanova +5 more
TL;DR: 16.1 Cytokine Biology: A General Introduction 315 16.2 CyTokine Polymorphisms and CytOKine Expression 317 16.3 Cytoksines and the Brain 318 16.8 Future Directions 322 References 322
Protective effects of antioxidant pretreatment in VPA-treated Nrf2 knockout mice
TL;DR: In this article, the authors present a list of figures of thesis of the thesis of the paper "Thesis of Thesis: Acknowledgements, acknowledgements, and acknowledgements.
Journal ArticleDOI
The Potential of Salivary Lipid-Based Cannabis-Responsive Biomarkers to Evaluate Medical Cannabis Treatment in Children with Autism Spectrum Disorder.
Michael Siani-Rose,Robert McKee,Stephany M Cox,Bonni Goldstein,Donald I. Abrams,Myiesha Taylor,Itzhak Kurek +6 more
TL;DR: It is suggested that lipid metabolites in saliva can potentially serve as cannabis-responsive biomarkers and objectively quantify the impact of MC treatment, and indicate a possible mechanism of action for MC.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?