Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
Neuroprotective effect of the standardised extract of Bacopa monnieri (BacoMind) in valproic acid model of autism spectrum disorder in rats.
M L Abhishek,Singla Rubal,Kumar C. Rohit,Joshi Rupa,Sarma Phulen,Kaur Gurjeet,Sarma Amit Raj,Prajapati Manisha,Bhatia Alka,Pallola Ramprasad,Medhi Bikash +10 more
TL;DR: In this paper , the authors evaluated the neuroprotective effect of Bacopa monnieri (BM) in experimental model of autism spectrum disorder (ASD) in Wistar rats and explore its mechanism of action.
Book ChapterDOI
The Redox/Methylation Hypothesis of Autism: A Molecular Mechanism for Heavy Metal-Induced Neurotoxicity
Journal ArticleDOI
The Impact of Oxidative Stress on Pediatrics Syndromes
Ginevra Micangeli,Michela Menghi,Giovanni Profeta,F. Tarani,Alessandro Mariani,Carla Petrella,Christian Barbato,Giampiero Ferraguti,Mauro Ceccanti,Luigi Tarani,Marco Fiore +10 more
TL;DR: In this article , a review of the literature showed that in some pathologies, such as fetal alcohol spectrum disorders, oxidative stress related to the intake of ethanol during pregnancy is a main etiological factor determining the associated clinical syndrome.
Patent
C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof
TL;DR: In this article, C17-alkanediyi and aikenediyl derivatives of oleanolic acid, including those of the formula (I), were defined, and methods and intermediates useful for making the compounds and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof were also provided.
Journal ArticleDOI
Picomolar glutathione detection based on the dual-signal self-calibration electrochemical sensor of ferrocene-functionalized copper metal-organic framework via solid-state electrochemistry of cuprous chloride.
TL;DR: In this article , an ultra-sensitive dual-signal intrinsic self-calibration electrochemical platform for GSH was firstly fabricated based on the novel electroactive nanomaterial of ferrocene-functionalized copper metal-organic framework (Fc-Cu-MOF).
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?