Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
Autism Spectrum Disorders: An Intervention Approach Based on Genomic Analysis
TL;DR: In this paper, the authors proposed a method based on DNA polymorphism analysis as the first step to characterize vulnerabilities related to different ASD subtypes in order to design more individualized therapeutic and support strategies.
Journal ArticleDOI
Role of cerium oxide nanoparticles in improving oxidative stress and developmental delays in Drosophila melanogaster as an in-vivo model for bisphenol a toxicity
Arkajyoti Sarkar,Tharun Selvam Mahendran,Aasha Meenakshisundaram,Rushenka Vashti Christopher,Pallavi Dan,Vignesh Sundararajan,Nishant Jana,Devanand Venkatasubbu,Sahabudeen Sheik Mohideen +8 more
TL;DR: In this article, the effects of exposure to different concentrations of BPA (0.05, 0.5, 1mM) were studied and the flies showed deficits in social interaction, locomotion, and enhanced oxidative stress that was found to be deteriorating among the flies.
Journal ArticleDOI
Developing a Deeper Understanding of Autism: Connecting Knowledge through Literature Mining.
TL;DR: A literature mining method to search for matched themes in unrelated literature that may contribute to a better understanding of complex pathological conditions, such as autism, confirms that this method could support experts on their way towards discovering hidden relationships and towards a betterUnderstanding of the disorder.
Journal ArticleDOI
Environmental Factors and Limbic Vulnerability in Childhood Autism
TL;DR: A two-hit combination of genetic susceptibility and environmental challenge is argued to underlie the rise in ASD.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?