Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Hormone Disorder and Vitamin Deficiency in Attention Deficit Hyperactivity Disorder (adhd) and Autism Spectrum Disorders (ASD)
TL;DR: In this article, the authors analyzed thyroid and antibodies, ferritin, vitamins B12 and D, adrenal and gonadal steroid levels, and celiac antibodies in children diagnosed with ADHD and autism spectrum disorder (ASD).
Journal ArticleDOI
The Frequency of Polymorphisms affecting Lead and Mercury Toxicity among Children with Autism
Shannon Rose,Stepan Melnyk,Alena Savenka,Amanda Hubanks,Stefanie Jernigan,Mario A. Cleves,S. Jill James +6 more
TL;DR: It is suggested that children with autism who inherit the ALAD2 allele with lower glutathione levels may be at increased risk for lead toxicity during prenatal and postnatal neurodevelopment.
Journal ArticleDOI
Diagnostic and Severity-Tracking Biomarkers for Autism Spectrum Disorder.
Geir Bjørklund,Nagwa A. Meguid,Afaf El-Ansary,Mona A. El-Bana,Maryam Dadar,Jan Aaseth,Maha Hemimi,Joško Osredkar,Salvatore Chirumbolo +8 more
TL;DR: A comprehensive review of the state of the art about major biomarkers reported in ASD and the association of some biomarkers with ASD symptoms and severity is presented in this article, where the authors comprehensively review state-of-the-art about ASD and their association with ASD symptom and severity.
Journal ArticleDOI
Thioredoxin is a novel diagnostic and prognostic marker in patients with ischemic stroke
TL;DR: Elevated TRX level at admission was a novel diagnostic and prognostic marker in patients with acute ischemic stroke and improved the area under the receiver operating characteristic curve of the NHISS score for functional outcome.
Journal ArticleDOI
Emerging Roles of Sonic Hedgehog in Adult Neurological Diseases: Neurogenesis and Beyond.
TL;DR: Examples are presented to show different aspects of Shh signaling and how Shh agonists or mimetics are used to alter the neuronal fates in various disease models, both in vitro and in vivo.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?