Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
More filters
Journal ArticleDOI
Brazilian medicinal plants with corroborated anti-inflammatory activities: a review
TL;DR: The collected data on Brazilian medicinal plants, in the form of crude extract and/or isolated compounds, showed significant anti-inflammatory activities involving different mechanisms of action, indicating Brazilian plants as an important source of anti- inflammatory compounds.
Journal ArticleDOI
Lack of correlation between metallic elements analyzed in hair by ICP-MS and autism.
TL;DR: A meta-analysis including the present and previous similar studies excluded any association of autism with hair concentrations of mercury, cadmium, selenium, lithium and copper, and a slight association was found for lead only, but it was very weak, as strictly dependent on the worst data from one study.
Journal ArticleDOI
Agmatine rescues autistic behaviors in the valproic acid-induced animal model of autism
Ji-Woon Kim,Hana Seung,Ki Chan Kim,Edson Luck Gonzales,Hyun Ah Oh,Sung Min Yang,Mee Jung Ko,Seol-Heui Han,Sourav Banerjee,Chan Young Shin +9 more
TL;DR: Experimental evidence is provided suggesting a possible therapeutic role of agmatine in ameliorating ASD‐like symptoms in the VPA animal model of ASD.
Journal ArticleDOI
The Roots of Autism and ADHD Twin Study in Sweden (RATSS).
Sven Bölte,Charlotte Willfors,Steve Berggren,Joakim Norberg,Lina Poltrago,Katell Mevel,Christina Coco,Peter Fransson,Jacqueline Borg,Rouslan Sitnikov,Roberto Toro,Kristiina Tammimies,Britt-Marie Anderlid,Ann Nordgren,Anna Falk,Urs Meyer,Juha Kere,Mikael Landén,Christina Dalman,Angelica Ronald,Henrik Anckarsäter,Paul Lichtenstein +21 more
TL;DR: The Roots of Autism and ADHD Twins Study in Sweden (RATSS) as discussed by the authors is an ongoing project targeting monozygotic twins discordant for categorical or dimensional autistic and inattentive/hyperactive-impulsive phenotypes as well as other neurodevelopmental disorders, and typically developing twin controls.
Journal ArticleDOI
The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism.
William Parker,Chi D. Hornik,Staci D. Bilbo,Zoie E. Holzknecht,Lauren Gentry,Rasika Rao,Shu S. Lin,Martha R. Herbert,Cynthia D. Nevison +8 more
TL;DR: One explanation for the increased prevalence of autism is that increased exposure to acetaminophen, exacerbated by inflammation and oxidative stress, is neurotoxic in babies and small children.
References
More filters
Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?