Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
More filters
Journal ArticleDOI
Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems.
TL;DR: Inhibition of free radical generating enzymes is inhibition of internal antioxidant enzymes and prevention of lipid peroxidation is prevention of DNA damage and protein modification.
Journal ArticleDOI
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
TL;DR: Evidence supports the notion that mitochondrial dysfunction is associated with autism spectrum disorders, and suggests children with ASD have a spectrum of mitochondrial dysfunction of differing severity.
Journal ArticleDOI
Consensus Paper: Pathological Role of the Cerebellum in Autism
S. Hossein Fatemi,Kimberly A. Aldinger,Paul Ashwood,Margaret L. Bauman,Charles D. Blaha,Gene J. Blatt,Abha Chauhan,Ved Chauhan,Stephen R. Dager,Price E. Dickson,Annette Estes,Dan Goldowitz,Detlef H. Heck,Thomas L. Kemper,Bryan H. King,Loren A. Martin,Kathleen J. Millen,Guy Mittleman,Matthew W. Mosconi,Antonio M. Persico,John A. Sweeney,Sara Jane Webb,John P. Welsh +22 more
TL;DR: The diversity of opinions regarding the involvement of this important site in the pathology of autism will be observed, and points of consensus include presence of abnormal cerebellar anatomy, abnormal neurotransmitter systems, oxidative stress, Cerebellar motor and cognitive deficits, and neuroinflammation in subjects with autism.
Journal ArticleDOI
The neurobiology of autism
TL;DR: The molecular pathways altered in autism are linked to the neurodevelopmental and clinical changes that characterize the disease, and evidence implicating oxidative stress, neuroglial activation and neuroimmunity is discussed.
Journal ArticleDOI
The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes
Jerzy Wegiel,Izabela Kuchna,Krzysztof Nowicki,Humi Imaki,Jarek Wegiel,Elaine Marchi,Shuang Yong Ma,Abha Chauhan,Ved Chauhan,Teresa Wierzba Bobrowicz,Mony J. de Leon,Mony J. de Leon,Leslie A. Saint Louis,Ira L. Cohen,Eric London,W. Ted Brown,Thomas Wisniewski +16 more
TL;DR: Deterioration in the patterns of focal qualitative developmental defects in the brains of autistic subjects reflects multiregional dysregulation of neurogenesis, neuronal migration and maturation in autism, which may contribute to the heterogeneity of the clinical phenotype.
References
More filters
Journal ArticleDOI
Increased Prevalence of Familial Autoimmunity in Probands With Pervasive Developmental Disorders
Thayne L. Sweeten,Suzanne L. Bowyer,David J. Posey,Gary M. Halberstadt,Christopher J. McDougle +4 more
TL;DR: The frequency of autoimmune disorders was significantly higher in families of the PDD probands compared with families of both the autoimmune and healthy control probands, and autoimmunity was increased significantly in families with PDD compared with those of healthy and autoimmune control subjects.
Journal ArticleDOI
Circulating autoantibodies to neuronal and glial filament proteins in autism
TL;DR: Clinically, there is a significant increase in incidence of anti-NAFP and anti-GFAP in autistic subjects, but not in MR subjects, and these autoantibodies may be related to autoimmune pathology in autism.
Journal ArticleDOI
Increased excretion of a lipid peroxidation biomarker in autism.
TL;DR: The results suggest that the lipid peroxidation biomarker is increased in this cohort of autisticChildren, especially in the subgroup of autistic children.
Journal ArticleDOI
Characterization of the major hydroperoxide-reducing activity of human plasma. Purification and properties of a selenium-dependent glutathione peroxidase.
TL;DR: The purification and kinetic parameters are suggestive of the potential of human plasma glutathione peroxidase as an important regulator of plasma hydroperoxide levels.
Journal ArticleDOI
Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism.
Suleyman Salih Zoroglu,Ferah Armutcu,Şakir Özen,Ahmet Gürel,Ercan Sivasli,Özer Yetki̇n,Iclal Meram +6 more
TL;DR: It is proposed that antioxidant status may be changed in autism and this new situation may induce lipid peroxidation, both of which may be relevant to the pathophysiology of autism.