Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Autism spectrum disorder (ASD): A current review of assessment, risk factors and prevention
G Balaji,Sukesh Narayan Sinha +1 more
TL;DR: Trends in assessment of this neurodevelopmental disorder, autism risk factors, and preventions for autism are reviewed, including screening tools for ASD and recommendations for preventions.
Journal ArticleDOI
Individuals with autism have higher 8-Iso-PGF2α levels than controls, but no correlation with quantitative assay of Paraoxonase 1 serum levels
TL;DR: Measurements of serum 8-Iso-Prostaglanding F2 α (8-iso-PGF2α, which is the results of non-enzimatically mediated polyunsaturated fatty acid oxidation) in a population of individuals with autism and a control group of age and sex matched controls show that patients diagnosed with autism have higher levels of this particular metabolite than their neurotypical counterparts.
Journal ArticleDOI
Empathy and Oxidative Stress in Healthy Adults
Agnieszka Żelaźniewicz,Judyta Nowak,Agata Groyecka,Piotr Sorokowski,Małgorzata Dobrowolska,Bogusław Pawłowski +5 more
TL;DR: The results showed that empathy is negatively related to oxidative stress level in men but not in women, when controlled for testosterone level, adding to growing evidence showing that many physiological mechanisms, other than hormonal factors, that may be also related with environmental harmful factors, are related to behavioral, affective and cognitive phenomena.
Potential Role of Penicillamine in the Early Diagnosis and Prevention ofAutism Spectrum Disorder (ASD)
TL;DR: Abbrevations ASD Autism Spectrum Disorder BG Basal Ganglia BBB Blood-Brain-Barrier BIND Bilirubin-Induced Neurologic Dysfunction INOS Inducible Nitric Oxide Synthase NO Nitric oxide NHBI Neonatal Hyperbilirubinemia LP Lipid Peroxidation OS Oxidative Stress NS Nitrosative Stress WD Wilson’s Disease
Patent
Aryl and arylalkyl substituted pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
Eric Anderson,Xin Jiang,Bender Christopher F,Gary L. Bolton,Caprathe Bradley,Chitase Lee,William H. Roark,Pamela Donner,Rolf Wagner,Jason Shanley,Howard Heyman,Allan Krueger,Hui-Ju Chen,Michael Rozema,David Grampovnik,Melean Visnick +15 more
TL;DR: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein R1, R2, R3, R4, R5, R6, m, n, X and Y are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation as mentioned in this paper.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?