Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Book ChapterDOI
Mitochondrial Dysfunction in Autism
Abha Chauhan,Feng Gu,Ved Chauhan +2 more
TL;DR: The evidence about mitochondrial dysfunction in autism is reviewed, including decreased activities and protein expression levels of ETC complexes, mtDNA or nDNA mutations, oxidative stress, and calcium-signaling abnormalities in autism.
Dissertation
GSTM1 Null, GSTT1 Null Gene and Low Erythrocyte GST Activity as Risk Factor of Autism Spectrum Disorder
TL;DR: The preliminary study was performed to investigate the role of GSTM1 and GSTT1 polymorphism as risk factor of ASD associated with GST activity and phenotype expression and to find out gene susceptibility of ASD and factors that contribute to the phenotype expression of ASD.
Journal ArticleDOI
A Review on Autism Spectrum Disorder: Pathogenesis, Biomarkers, Pharmacological and Non-Pharmacological Interventions.
TL;DR: An urgent need is to create brain-targeted delivery methods for dietary phytochemicals including curcumin, resveratrol, naringenin, and sulforaphane to investigate their therapeutic value in ASD.
Journal Article
Effect of mild hyperbaric oxygen therapy on children diagnosed with autism.
Alex Rizzato,Natalie D’Alessandro,Elisabetta Berenci,Alice Rinchi,Garrett Enten,Giuliano Vezzani,Maurizio Proietti,Alberto Fiorito,Enrico M. Camporesi,Gerardo Bosco +9 more
TL;DR: The results do not support the utility of HBO2 in children diagnosed with autism as the primary treatment modality for inflammatory pathways related to neurological disorders.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?