Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
Critical Evaluation of Valproic Acid-Induced Rodent Models of Autism: Current and Future Perspectives
TL;DR: A review of the preclinical and neurobiological relevant validated features, involved etiological mechanism, biological markers, treatment responses, drawbacks, current approaches, and future perspectives of VPA-induced model of autism would help in deciphering the validation of the Vpa-induced autistic model and its suitability as an experimental model of Autism.
Journal ArticleDOI
Parvalbumin and parvalbumin chandelier interneurons in autism and other psychiatric disorders
TL;DR: The role of PV and PV+ Ch cell alterations in ASD and other psychiatric disorders is reviewed.
Effect of Sulfamerazine on Plasma Ceruloplasmin Levels in Rainbow Trout (Onchorhynchus Mykiss, Walbaum, 1792)
TL;DR: The plasma Cp levels in fish fed with three different doses of sulfamerazine are significantly higher (p<0.01, p <0.001) than those in control fish.
Journal ArticleDOI
Effect of rutin on oxidative DNA damage in PC12 neurons cultured in nutrients deprivation condition.
TL;DR: Rutin inhibits oxidative DNA damage and neuronal death induced by nutrients deprivation condition and may warrant the use of rutin as an appropriate neuroprotective agent for ischemic attacks and other neurodegenerative disorders.
Book ChapterDOI
A case study: impact of Internet of Things devices and pharma on the improvements of a child in autism
TL;DR: The triangle of IoT, pharma, and autism works very well for Mujtaba, a 10.5-year-old boy with Asperger syndrome, and his communication and socialization is now better than before.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?