Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems.
TL;DR: Inhibition of free radical generating enzymes is inhibition of internal antioxidant enzymes and prevention of lipid peroxidation is prevention of DNA damage and protein modification.
Journal ArticleDOI
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
TL;DR: Evidence supports the notion that mitochondrial dysfunction is associated with autism spectrum disorders, and suggests children with ASD have a spectrum of mitochondrial dysfunction of differing severity.
Journal ArticleDOI
Consensus Paper: Pathological Role of the Cerebellum in Autism
S. Hossein Fatemi,Kimberly A. Aldinger,Paul Ashwood,Margaret L. Bauman,Charles D. Blaha,Gene J. Blatt,Abha Chauhan,Ved Chauhan,Stephen R. Dager,Price E. Dickson,Annette Estes,Dan Goldowitz,Detlef H. Heck,Thomas L. Kemper,Bryan H. King,Loren A. Martin,Kathleen J. Millen,Guy Mittleman,Matthew W. Mosconi,Antonio M. Persico,John A. Sweeney,Sara Jane Webb,John P. Welsh +22 more
TL;DR: The diversity of opinions regarding the involvement of this important site in the pathology of autism will be observed, and points of consensus include presence of abnormal cerebellar anatomy, abnormal neurotransmitter systems, oxidative stress, Cerebellar motor and cognitive deficits, and neuroinflammation in subjects with autism.
Journal ArticleDOI
The neurobiology of autism
TL;DR: The molecular pathways altered in autism are linked to the neurodevelopmental and clinical changes that characterize the disease, and evidence implicating oxidative stress, neuroglial activation and neuroimmunity is discussed.
Journal ArticleDOI
The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes
Jerzy Wegiel,Izabela Kuchna,Krzysztof Nowicki,Humi Imaki,Jarek Wegiel,Elaine Marchi,Shuang Yong Ma,Abha Chauhan,Ved Chauhan,Teresa Wierzba Bobrowicz,Mony J. de Leon,Mony J. de Leon,Leslie A. Saint Louis,Ira L. Cohen,Eric London,W. Ted Brown,Thomas Wisniewski +16 more
TL;DR: Deterioration in the patterns of focal qualitative developmental defects in the brains of autistic subjects reflects multiregional dysregulation of neurogenesis, neuronal migration and maturation in autism, which may contribute to the heterogeneity of the clinical phenotype.
References
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Journal ArticleDOI
Mumps, measles, and rubella vaccine and the incidence of autism recorded by general practitioners: a time trend analysis
TL;DR: Evidence is provided that no correlation exists between the prevalence of MMR vaccination and the rapid increase in the risk of autism over time, and the explanation for the marked increase in risk of the diagnosis of autism in the past decade remains uncertain.
Journal ArticleDOI
Follow-up report on autism in congenital rubella.
TL;DR: Examination of the data suggested that the rubella virus was the primary etiologic agent, and it was hypothesized that the course of autism was that of a chronic infection in which recovery, chronicity, improvement, worsening, and delayed appearance of the autistic syndrome all were found.
Journal ArticleDOI
Transferrin and Iron in Normal, Alzheimer's Disease, and Parkinson's Disease Brain Regions
David A. Loeffler,James R. Connor,P. L. Juneau,B. S. Snyder,L. Kanaley,A. J. DeMaggio,H.-U. Nguyen,C. M. Brickman,Peter A. LeWitt +8 more
TL;DR: The altered relationship between iron and transferrin provides further evidence that a disturbance in iron metabolism may be involved in both Alzheimer's and Parkinson's disease.
Journal ArticleDOI
Measles, mumps, and rubella vaccination and bowel problems or developmental regression in children with autism: population study.
TL;DR: Findings provide no support for an MMR associated “new variant” form of autism with developmental regression and bowel problems, and further evidence against involvement of MMR vaccine in the initiation of autism.
Journal ArticleDOI
Elevated cytokine levels in children with autism spectrum disorder
Cynthia A. Molloy,Cynthia A. Molloy,Ardythe L. Morrow,Ardythe L. Morrow,Jareen Meinzen-Derr,Kathleen W. Schleifer,Krista Dienger,Patricia Manning-Courtney,Patricia Manning-Courtney,Mekibib Altaye,Mekibib Altaye,Marsha Wills-Karp,Marsha Wills-Karp +12 more
TL;DR: Children with ASD had increased activation of both Th2 and Th1 arms of the adaptive immune response, with a Th2 predominance, and without the compensatory increase in the regulatory cytokine IL-10.