Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems.
TL;DR: Inhibition of free radical generating enzymes is inhibition of internal antioxidant enzymes and prevention of lipid peroxidation is prevention of DNA damage and protein modification.
Journal ArticleDOI
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
TL;DR: Evidence supports the notion that mitochondrial dysfunction is associated with autism spectrum disorders, and suggests children with ASD have a spectrum of mitochondrial dysfunction of differing severity.
Journal ArticleDOI
Consensus Paper: Pathological Role of the Cerebellum in Autism
S. Hossein Fatemi,Kimberly A. Aldinger,Paul Ashwood,Margaret L. Bauman,Charles D. Blaha,Gene J. Blatt,Abha Chauhan,Ved Chauhan,Stephen R. Dager,Price E. Dickson,Annette Estes,Dan Goldowitz,Detlef H. Heck,Thomas L. Kemper,Bryan H. King,Loren A. Martin,Kathleen J. Millen,Guy Mittleman,Matthew W. Mosconi,Antonio M. Persico,John A. Sweeney,Sara Jane Webb,John P. Welsh +22 more
TL;DR: The diversity of opinions regarding the involvement of this important site in the pathology of autism will be observed, and points of consensus include presence of abnormal cerebellar anatomy, abnormal neurotransmitter systems, oxidative stress, Cerebellar motor and cognitive deficits, and neuroinflammation in subjects with autism.
Journal ArticleDOI
The neurobiology of autism
TL;DR: The molecular pathways altered in autism are linked to the neurodevelopmental and clinical changes that characterize the disease, and evidence implicating oxidative stress, neuroglial activation and neuroimmunity is discussed.
Journal ArticleDOI
The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes
Jerzy Wegiel,Izabela Kuchna,Krzysztof Nowicki,Humi Imaki,Jarek Wegiel,Elaine Marchi,Shuang Yong Ma,Abha Chauhan,Ved Chauhan,Teresa Wierzba Bobrowicz,Mony J. de Leon,Mony J. de Leon,Leslie A. Saint Louis,Ira L. Cohen,Eric London,W. Ted Brown,Thomas Wisniewski +16 more
TL;DR: Deterioration in the patterns of focal qualitative developmental defects in the brains of autistic subjects reflects multiregional dysregulation of neurogenesis, neuronal migration and maturation in autism, which may contribute to the heterogeneity of the clinical phenotype.
References
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Journal ArticleDOI
The Neurobiological Context of Autism
Flavio Keller,Antonio M. Persico +1 more
TL;DR: Considerations suggest that a non-deterministic conceptual framework is highly appropriate for autism research, as well as the role of environmental factors, which are still poorly characterized.
Journal ArticleDOI
Phospholipid Spectrum Disorder in Psychiatry
TL;DR: For instance, a National Institute of Health workshop in Washington DC in 1998, organised by Joe as discussed by the authors, considered neurobiological research in psychiatry to be unhelpfully skewed towards neurotransmitter receptors and away from the lipid characteristics of the membrane environment of those receptors.
Journal ArticleDOI
Genetic investigation of quantitative traits related to autism: use of multivariate polygenic models with ascertainment adjustment.
Yun Ju Sung,Geraldine Dawson,Jeffrey Munson,Annette Estes,Gerard D. Schellenberg,Gerard D. Schellenberg,Ellen M. Wijsman +6 more
TL;DR: Evidence for a genetic basis of several quantitative traits that are related to autism is provided and it is suggested that they may be most promising for future gene mapping and for extending pedigrees by phenotyping additional relatives.
Journal ArticleDOI
Autism and congenital cytomegalovirus
E G Stubbs,E Ash,C P Williams +2 more
TL;DR: The viral hypothesis of autism is discussed along with a brief review of the literature and Suggestions are made for future research.