Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
The Autistic Phenotype Exhibits a Remarkably Localized Modification of Brain Protein by Products of Free Radical-Induced Lipid Oxidation
Teresa A. Evans,Sandra L. Siedlak,Liang Lu,Xiaoming Fu,Zeneng Wang,Woody R. McGinnis,Evelyn Fakhoury,Rudy J. Castellani,Stanley L. Hazen,William J. Walsh,Allen Lewis,Robert G. Salomon,Mark A. Smith,George Perry,Xiongwei Zhu +14 more
TL;DR: It seems likely that oxidative injury of proteins in the brain would be associated with neurological abnormalities and provide a cellular basis at the root of autism spectrum disorders.
Journal ArticleDOI
Altered neurotrophin, neuropeptide, cytokines and nitric oxide levels in autism.
Márcia Helena Fávero de Souza Tostes,Henrique Couto Teixeira,Wagner F. Gattaz,Marcos Antônio Fernandes Brandão,Nádia Rezende Barbosa Raposo,Nádia Rezende Barbosa Raposo +5 more
TL;DR: The results indicate the presence of altered levels of neurotrophin and neuropeptide in infantile autism and provide additional evidence that higher levels of IFN-γ may be associated with increased oxidative stress in autism.
Journal ArticleDOI
DNA Damage and Repair in Schizophrenia and Autism: Implications for Cancer Comorbidity and Beyond.
TL;DR: The current evidence of cancer comorbidity in these brain disorders is summarized and the putative roles of oxidative stress, DNA damage and DNA repair in the aetiopathology of schizophrenia and ASD are discussed.
Journal ArticleDOI
Relationships among Parvalbumin-Immunoreactive Neuron Density, Phase-Locked Gamma Oscillations, and Autistic/Schizophrenic Symptoms in PDGFR-β Knock-Out and Control Mice
Tomoya Nakamura,Jumpei Matsumoto,Yusaku Takamura,Yoko Ishii,Masakiyo Sasahara,Taketoshi Ono,Hisao Nishijo +6 more
TL;DR: It is suggested that phase-locked gamma oscillations could be a useful physiological biomarker for abnormality of parvalbumin-immunoreactive neurons that may induce cognitive deficits and negative symptoms of schizophrenia and autism, as well as of effective pharmacological interventions in both humans and experimental animals.
Journal ArticleDOI
Evidence of Mitochondrial Dysfunction in Autism: Biochemical Links, Genetic-Based Associations, and Non-Energy-Related Mechanisms.
TL;DR: Evidence of a link between mitochondrial dysfunction and autism spectrum disorder is reviewed, specifically on biochemical links, genetic-based associations, non-energy related mechanisms, and novel therapeutic strategies.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?