Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
Oral microbiota and autism spectrum disorder (ASD).
Ingar Olsen,Steven D. Hicks +1 more
TL;DR: A possible relationship between oral bacteria and the biologic and symptomologic aspects of ASD is discussed, focusing on the clinical implications for diagnostic and therapeutic development.
Journal ArticleDOI
The concomitant lower concentrations of vitamins B6, B9 and B12 may cause methylation deficiency in autistic children.
TL;DR: The concomitant deficiencies of all three B vitamins, recorded in a significant number of autistic children, suggests that intestinal dysbiosis in these patients may be the main cause of a reduction in their absorption, in addition to the genetic mutation of a specific gene.
The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes Jerzy WegielIzabela KuchnaKrzysztof NowickiHumi ImakiJarek WegielElaine Marchi • Shuang Yong MaAbha ChauhanVed ChauhanTeresa Wierzba BobrowiczMony de Leon • Leslie A. Saint LouisIra L. CohenEric LondonW. Ted BrownThomas Wisniewski
M. de Leon,Leslie A. Saint Louis,Thomas Wisniewski,Louis T. Wisniewski,Chauhan V. Chauhan,Teresa Wierzba Bobrowicz,Eric London,W. T. Brown +7 more
TL;DR: In this paper, the brain hemispheres of 13 autistic (4-60 years of age) and 14 age-matched control subjects were embedded in celloidin and cut into 200 lm-thick coronal sections, which were stained with cresyl violet and used for neuropathological evalua- tion.
Journal ArticleDOI
Serum levels of SOD and risk of autism spectrum disorder: A case-control study.
TL;DR: This study examined the clinical significance of serum superoxide dismutase level, a marker of oxidative stress, in children with autism spectrum disorder (ASD) and typically‐developing children between the ages of 2 and 6 years.
Journal ArticleDOI
Gene-Environment Interactions in Developmental Neurotoxicity: a Case Study of Synergy between Chlorpyrifos and CHD8 Knockout in Human BrainSpheres.
Sergio Modafferi,Sergio Modafferi,Xiali Zhong,Xiali Zhong,Andre Kleensang,Yohei Murata,Francesca Fagiani,Francesca Fagiani,Francesca Fagiani,David Pamies,David Pamies,Helena T. Hogberg,Vittorio Calabrese,Herbert M. Lachman,Thomas Hartung,Thomas Hartung,Lena Smirnova +16 more
TL;DR: In this article, the mechanism of gene-environment interactions and reliable bi-particle bi-connections were used to diagnose autism spectrum disorder (ASD) caused by complex genetic and environmental components.
References
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Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
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The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
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Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?