Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
Paraoxonase 1 activities and polymorphisms in autism spectrum disorders.
Sergiu P. Paşca,Eleonora Dronca,Bogdan Nemes,Tamás Kaucsár,Emoke Endreffy,Felicia Iftene,Ileana Benga,Rodica Cornean,Maria Dronca +8 more
TL;DR: Both the bioavailability and the catalytic activity of Pon1 are impaired in ASD, despite no association with the Q192R and L55M polymorphisms in the PON1 gene and a normal distribution of the P ON1 phenotype.
Journal ArticleDOI
Thioredoxin: a novel, independent diagnosis marker in children with autism.
TL;DR: Assessment of the clinical significance of serum TRX levels in Autism spectrum disorders (ASD) found redox‐regulating protein with antioxidant activity recognized as an oxidative‐stress marker to be positive.
Journal ArticleDOI
Peroxidase-ROS interactions
TL;DR: A well-tested model of the peroxidase–oxidases (PO) reaction based on horseradish peroxIDase (HRP) chemistry with regard to the production and consumption of hydrogen peroxide and superoxide finds that PO reactions can manifest low frequency bursting whereby pulses of ROS are produced at clinically significant intervals.
Journal ArticleDOI
Redox Regulation and the Autistic Spectrum: Role of Tryptophan Catabolites, Immuno-inflammation, Autoimmunity and the Amygdala
George M. Anderson,Michael Maes +1 more
TL;DR: An early developmental model is proposed whereby different ASD genetic susceptibilities interact with environmental and epigenetic processes, resulting in glia biasing the patterning of central interarea interactions, and a role for decreased local melatonin and N-acetylserotonin production by immune and glia cells may be a significant treatment target.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
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Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?