Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
The Inferior Colliculus in Alcoholism and Beyond.
TL;DR: Multimodal imaging including diffusion methods to provide more accurate in vivo visualization and quantification of the inferior colliculi may clarify the roles of brain stem nuclei such as the inferiorColliculi in alcoholism and other neuropathologies marked by altered metabolism.
Journal ArticleDOI
Lactonase Activity and Lipoprotein-Phospholipase A2 as Possible Novel Serum Biomarkers for the Differential Diagnosis of Autism Spectrum Disorders and Rett Syndrome: Results from a Pilot Study.
TL;DR: Results suggest that lactonase and, especially, Lp-PLA2 activities might represent novel candidate biomarkers for ASD.
Book ChapterDOI
Is Taurine a Biomarker in Autistic Spectrum Disorder
Eunkyue Park,Ira L. Cohen,Maripaz G. Gonzalez,Mario R. Castellano,Michael Flory,Edmund C. Jenkins,W. Ted Brown,Georgia Schuller-Levis +7 more
TL;DR: The data imply that taurine may be a valid biomarker in a subgroup of ASD, and children with ASD with low t aurine concentrations will be examined for abnormal mitochondrial function.
Journal ArticleDOI
Reduced activity of protein kinase C in the frontal cortex of subjects with regressive autism: relationship with developmental abnormalities.
Lina Ji,Abha Chauhan,Ved Chauhan +2 more
TL;DR: Brain region-specific alteration of PKC activity in the frontal cortex of subjects with regressive autism is suggested, in part, to alterations in G-protein-coupled receptor-mediated signal transduction involving PKA and PKC inThe frontal cortex.
Journal ArticleDOI
Sulforaphane treatment for autism spectrum disorder: A systematic review.
Greer McGuinness,Yeonsoo Kim +1 more
TL;DR: The current evidence shows with minimal side effects observed, SFN appears to be a safe and effective treatment option for treating ASD.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
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Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?