Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Studies on H1N1 vaccine-induced monoamines alternations and oxidative stress on brain of adult mice
TL;DR: It is demonstrated that H1N1 vaccine as a whole and/or its ingredient caused oxidative stress and monoamines alternations in brain of mice.
Journal ArticleDOI
The Role of Neurodevelopmental Genes in Infectious Etiology of Autism
TL;DR: Several brain genes of interest in this animal model are also involved in the pathology of autism, and the roles of these genes in brain development are discussed in this review.
Book ChapterDOI
Contribution of Oxidative Stress to the Pathophysiology of Autism Spectrum Disorders: Impact of Genetic and Environmental Factors
Ved Chauhan,Abha Chauhan +1 more
TL;DR: Evidence of increased oxidative damage coupled with reduced antioxidant defense, genetic susceptibility to oxidative/nitrosative stress, and impact of environmental agents in autism is reviewed.
Lower Erythrocyte GST Activity in Autism Spectrum Disorder (ASD) Patients Compared to Normal Controls
TL;DR: The results showed no significant differences in frequencies of GSTM1 null, GSTT1 null and combination both genotype between ASD patients and controls, however the mean erythrocyte GST activity in ASD is significantly decreased compared with controls, although it was not statistically significant.
Journal ArticleDOI
Effects of Supplementation With Antioxidant Agents on Sleep in Autism Spectrum Disorder: A Review.
TL;DR: In this paper, a review of the current state of the literature on the effect of antioxidant treatment on sleep disturbances in patients with ASD is presented, which includes 15 studies involving Melatonin, 1 Tryptophan and 5 focused on supplementation with other antioxidant agents (namely Coenzyme Q10, L-Carnosine, Luteolin and Quercetin).
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?