Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
Active ribosomal genes, translational homeostasis and oxidative stress in the pathogenesis of schizophrenia and autism.
Lev N. Porokhovnik,Vladimir P. Passekov,Nataliya L. Gorbachevskaya,Alexander B. Sorokin,Nataliya N. Veiko,N. A. Lyapunova +5 more
TL;DR: The findings confirm the hypothesis of disturbance of the ‘translational homeostasis’ in the pathogeneses of autism and schizophrenia, and would help explain why oxidative stress markers are discovered in most autism studies, whereas similar reports related to schizophrenia are far less consistent.
Journal ArticleDOI
Plasma peroxiredoxin changes and inflammatory cytokines support the involvement of neuro-inflammation and oxidative stress in Autism Spectrum Disorder.
Provvidenza Maria Abruzzo,Alessandro Matte,Alessandra Bolotta,Enrica Federti,Alessandro Ghezzo,Tiziana Guarnieri,Marina Marini,Annio Posar,Angela Siciliano,L De Franceschi,Paola Visconti +10 more
TL;DR: The whole of the results, using peripheral data collected in living patients, support the involvement of neuro- inflammationation in ASD, and generate a rational for neuro-inflammation as a possible therapeutic target and for plasma Prx5 as a novel indicator of ASD severity.
Journal ArticleDOI
Decreased levels of serum retinoic acid in chinese children with autism spectrum disorder
TL;DR: It is suggested that serum RA levels were reduced in the group with ASD, and the levels negative correlated significantly with the severity of autism.
Journal ArticleDOI
Rare Single Nucleotide Polymorphisms in the Regulatory Regions of the Superoxide Dismutase Genes in Autism Spectrum Disorder
Jernej Kovač,Marta Macedoni Lukšič,Katarina Trebušak Podkrajšek,Gašper Klančar,Tadej Battelino +4 more
TL;DR: Using the optimized high‐resolution melting (HRM) analysis, two rare single nucleotide polymorphisms (SNPs) are identified associated with the etiology of ASD and are located in the noncoding potentially regulatory regions of the SOD1 gene.
Journal ArticleDOI
Study of the C677T and 1298AC polymorphic genotypes of MTHFR Gene in autism spectrum disorder.
Farida El-Baz,Mohammed Abd El-Aal,Tarek Moustafa Kamal,Abdelrahim Abdrabou Sadek,Amr Ahmed Othman +4 more
TL;DR: There is a significant association between severity and occurrence of autism with MTHFR gene polymorphisms C677T and A1298C among children with autism and among patients with severe autism (according to CARS).
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?