Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Artículos originAles Alteraciones del estado redox celular en pacientes cubanos con trastornos del espectro autista. Alterations in the cellular redox state in cuban patients with autistic spectrum disorders.
Deinys Carmenates Naranjo,I Giselle,Monzón Benítez,Roberto Lardoeyt,Gretel Riverón Forment,Arianne Llamos +5 more
TL;DR: Los resultados del estudio sugieren the presencia of condiciones de estres oxidativo en los pacientes con trastornos del espectro autista, y deberan ser replicadas en un mayor numero of casos por su posible utilidad in estrategias terapeuticas.
Book ChapterDOI
Achieving Optimal Outcomes in Autism: Treating Potentially Reversible Conditions Associated with Autism Spectrum Disorder
Journal ArticleDOI
Concentrations of Lead, Mercury, Arsenic, Cadmium, Manganese, and Aluminum in the Blood of Pakistani Children with and without Autism Spectrum Disorder and Their Associated Factors
Mohammad H. Rahbar,Shahnaz Ibrahim,Syed Iqbal Azam,Manouchehr Hessabi,Fatima Karim,Sori Kim,Jing Zhang,Nasreen Gulzar Ali,Katherine A. Loveland +8 more
TL;DR: In this paper, the association of ASD among Pakistani children with the six metals and genotype frequencies of three GST genes (GSTP1, GSTM 1, GSTT1) was assessed using conditional logistic regression models.
A Whole-Body Systems Approach to ASD
TL;DR: It will be important to develop awareness of whole-body and systems issues in autism, in order to include them in thorough appreciation and documentation of clinical history, and to more fully appreciate scientifi c and clinical advances in these autism-relevant domains.
Journal ArticleDOI
Neuroinflammation and Oxidative Stress in Individuals Affected by DiGeorge Syndrome
Michela Menghi,Ginevra Micangeli,F. Tarani,Carolina Putotto,Federica A. Pirro,Alessandro Mariani,Carla Petrella,Federica Pulvirenti,Bianca Cinicola,F. Colloridi,Luigi Tarani,Marco Fiore +11 more
TL;DR: In this paper , the correlation between oxidative stress and neuroinflammation in DGS patients with microdeletions of the 22q11.2 region was discussed, which could lead to reactive oxygen species (ROS) increased production and antioxidant depletion.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?