Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems.
TL;DR: Inhibition of free radical generating enzymes is inhibition of internal antioxidant enzymes and prevention of lipid peroxidation is prevention of DNA damage and protein modification.
Journal ArticleDOI
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
TL;DR: Evidence supports the notion that mitochondrial dysfunction is associated with autism spectrum disorders, and suggests children with ASD have a spectrum of mitochondrial dysfunction of differing severity.
Journal ArticleDOI
Consensus Paper: Pathological Role of the Cerebellum in Autism
S. Hossein Fatemi,Kimberly A. Aldinger,Paul Ashwood,Margaret L. Bauman,Charles D. Blaha,Gene J. Blatt,Abha Chauhan,Ved Chauhan,Stephen R. Dager,Price E. Dickson,Annette Estes,Dan Goldowitz,Detlef H. Heck,Thomas L. Kemper,Bryan H. King,Loren A. Martin,Kathleen J. Millen,Guy Mittleman,Matthew W. Mosconi,Antonio M. Persico,John A. Sweeney,Sara Jane Webb,John P. Welsh +22 more
TL;DR: The diversity of opinions regarding the involvement of this important site in the pathology of autism will be observed, and points of consensus include presence of abnormal cerebellar anatomy, abnormal neurotransmitter systems, oxidative stress, Cerebellar motor and cognitive deficits, and neuroinflammation in subjects with autism.
Journal ArticleDOI
The neurobiology of autism
TL;DR: The molecular pathways altered in autism are linked to the neurodevelopmental and clinical changes that characterize the disease, and evidence implicating oxidative stress, neuroglial activation and neuroimmunity is discussed.
Journal ArticleDOI
The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes
Jerzy Wegiel,Izabela Kuchna,Krzysztof Nowicki,Humi Imaki,Jarek Wegiel,Elaine Marchi,Shuang Yong Ma,Abha Chauhan,Ved Chauhan,Teresa Wierzba Bobrowicz,Mony J. de Leon,Mony J. de Leon,Leslie A. Saint Louis,Ira L. Cohen,Eric London,W. Ted Brown,Thomas Wisniewski +16 more
TL;DR: Deterioration in the patterns of focal qualitative developmental defects in the brains of autistic subjects reflects multiregional dysregulation of neurogenesis, neuronal migration and maturation in autism, which may contribute to the heterogeneity of the clinical phenotype.
References
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Journal ArticleDOI
Cholinergic activity in autism: abnormalities in the cerebral cortex and basal forebrain.
Elaine K. Perry,M. Lee,Carmen Martin-Ruiz,Jennifer A. Court,Stephen G. Volsen,Jenny Merrit,Elizabeth A. Folly,Portia E. Iversen,Margaret L. Bauman,Robert H. Perry,Gary L. Wenk +10 more
TL;DR: These neurochemical abnormalities implicate the cholinergic system in developmental disorders such as autism and suggest the potential for intervention based on cholinerential receptor modulation.
Journal ArticleDOI
Lipid peroxidation and mechanisms of toxicity.
Alan A. Horton,Steven Fairhurst +1 more
TL;DR: The possibility exists that certain foreign compounds may interfere with or even overwhelm these defenses, and herein could lie a general mechanism of toxicity.
Journal Article
Oxidative stress in autism.
TL;DR: The role of oxidative stress may help illuminate the pathophysiology of autism, its environmental and genetic influences, new treatments, and prevention, and how anti-oxidant nutrients are used in the contemporary treatment of autism.
Journal ArticleDOI
Density and distribution of hippocampal neurotransmitter receptors in autism: an autoradiographic study.
Gene J. Blatt,Claudia M. Fitzgerald,Jeffrey T. Guptill,Anne B. Booker,Thomas L. Kemper,Margaret L. Bauman +5 more
TL;DR: Data from single concentration ligand binding studies indicate that the GABAergic receptor system is significantly reduced in high binding regions, marking for the first time an abnormality in the GABA system in autism.
Journal ArticleDOI
Association between a GABRB3 polymorphism and autism.
Joseph D. Buxbaum,Jeremy M. Silverman,Christopher J. Smith,David A. Greenberg,Mario Kilifarski,Jennifer Reichert,Edwin H. Cook,Fang Y,C.-Y. Song,R. Vitale +9 more
TL;DR: Findings support a role for genetic variants within the GABA receptor gene complex in 15q11–13 in autistic disorder, and use of multi-allelic TDT (MTDT) and transmission disequilibrium test (TDT) demonstrated an association between autistic disorder and 155CA-2 in these families.