Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
More filters
Journal ArticleDOI
Oxidative Stress in Egyptian Children with Autism: Relation to Autoimmunity
TL;DR: The strong association between oxidative stress and autoimmunity in autistic children may indicate the possible role of oxidative stress, through induction of autoim immunotherapy, in some autistic patients.
Journal ArticleDOI
Current Neuropharmacological Interventions in Autism: Potential Drug Targets from Pre-clinical and Clinical Findings
TL;DR: Findings suggest that malfunctions of propionic acid-disrupted neuronal mitochondrial coenzyme Q10 (CoQ10) and etc-complexes are the most pathogenic events for autism.
Journal ArticleDOI
Scalp Acupuncture improves disordered behavior in the valproic acid-induced rat model of autism
Long-Sheng Huang,Pin Ge,Jie Kang,Gui-Hua Liu,Yu-fang Hong,Jing-Rong Wang,Chuanfeng Chen,Wanyu Zhuang,Jing-Min Guo,Ye-Bin Feng,Hongke Zhang,Ping Ou +11 more
TL;DR: In this paper , the underlying mechanisms of scalp acupuncture treatment (SAT) on autism spectrum disorder (ASD) were investigated, with 30 male Wistar rat pups that had been prenatally exposed to valproic acid sodium (VPA) were randomly divided into the VPA, VPA+acupoint, and VPA+, non-acuposition groups using the random number table method, with 10 rats in each group.
Antioksidan Vitaminler ve Psikiyatride Kullanimi Antioxidant Vitamins and Their Use in Psychiatry
TL;DR: Oxidative stress, which is included in the pathogenesis of cancer, aging, cardiovascular and neurodegenerative disorders, is also consi- dered for pathogenetic mechanisms underlying psychiatric disorders including schizophrenia, mood disorders, attention deficit hyperactivity disorder.
Journal ArticleDOI
Melatonin: the Weapon Against Oxidative Stress and Nitrosative Stress in Neurovascular Diseases
TL;DR: The multiple lines of evidence demonstrate that melatonin exerts powerful antioxidant actions by preventing and scavenging free radicals in a direct and indirect manner, and reduced post-ischemic oxidative/ nitrosative damage to the afflicted neurovascular units and improved the preservation of blood-brain barrier permeability in various brain diseases.
References
More filters
Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?