Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Book ChapterDOI
Abnormalities in Membrane Lipids, Membrane-Associated Proteins, and Signal Transduction in Autism
Ved Chauhan,Abha Chauhan +1 more
Journal ArticleDOI
Impaired Redox Control in Autism Spectrum Disorders: Could It Be the X in GxE?
Vanja Mandic-Maravic,Marija Pljesa-Ercegovac,Marija Mitkovic-Voncina,Ana Savic-Radojevic,Dusica Lecic-Tosevski,Dusica Lecic-Tosevski,Tatjana Simic,Milica Pejovic-Milovancevic +7 more
TL;DR: There might be a potentially significant specific gene-environment interaction in ASD, which is associated with oxidative stress, and revealing novel susceptibility genes, or environmental factors that might increase susceptibility to ASD in carriers of a specific genotype, might enable the stratification of individuals more prone to developing ASD.
Journal ArticleDOI
Carbosulfan exposure during embryonic period can cause developmental disability in rats.
TL;DR: Largely, alteration in behavior can be due to oxidative damage, thereby, affecting neurogenesis, synaptogenesis and myelination, and the propensity of carbosulfan to induce developmental disability is high and should be cautiously avoided during embryonic development.
Patent
2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof
TL;DR: The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR 6bS 8aR 12aS 14aR 14bS)-11-cyano.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?