Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
Toxins, Malnutrition, Stress, Infections and Electromagnetic Pollution:Looking about New Perspectives in Development of Diseases
Peres Ha,Pereira Lrl,Foss Mcf +2 more
TL;DR: There is need paradigm change in the medical model for investigate these factors in patients because currently this is not being done.
Journal ArticleDOI
Purine metabolism and oxidative stress in children with autistic spectrum disorders
TL;DR: Patients with ASD have impaired purine metabolism and increased oxidative stress which was supported by low levels of ADA and SOD, and high level of MDA, and further biochemical or genetic studies are required to explore the nature of autism.
Journal ArticleDOI
Emerging Clues and Altered Metabolic Findings in Autism: Breakthroughs andProspects from Omics Studies
TL;DR: The underpinnings of clinical challenges posed by ASD are delineated, like clinical heterogeneity of patient presentation, unresolved ASD genomic map and deficient drug therapy, and the emerging pathogenic, etiologic, and diagnostic clues of diverse origins, as availed by advances in Omics technologies.
Book ChapterDOI
Oxidative Stress and Mitochondrial Dysfunction in ASDs
Feng Gu,Ved Chauhan,Abha Chauhan +2 more
Assessment of Metabolic Parameters For Autism Spectrum Disorders
TL;DR: The guidelines in this article have been developed to assist the clinician in the consideration of different factors in deciding upon the appropriate evaluation scheme for autistic symptoms.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?