Journal ArticleDOI
Oxidative stress in autism
Abha Chauhan,Ved Chauhan +1 more
TLDR
Increases in oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 569 citations till now. The article focuses on the topics: Autism & Oxidative stress.read more
Citations
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Journal ArticleDOI
A review of candidate urinary biomarkers for autism spectrum disorder
TL;DR: There is scope for specific urinary biomarkers to be useful for identification of autistic metabolic phenotypes, according to the key theories regarding the etiology of autism.
Journal ArticleDOI
Metabolic theory of septic shock.
TL;DR: Evidence is presented that elevated systemic levels of hydrogen peroxide are present in septic shock victims and that it significantly contributes to the development and progression of this frequently lethal condition.
Journal ArticleDOI
Isoprostanes and 4-Hydroxy-2-nonenal: Markers or Mediators of Disease? Focus on Rett Syndrome as a Model of Autism Spectrum Disorder
Cinzia Signorini,Claudio De Felice,Thierry Durand,Camille Oger,Jean-Marie Galano,Silvia Leoncini,Alessandra Pecorelli,Giuseppe Valacchi,Giuseppe Valacchi,Lucia Ciccoli,Joussef Hayek +10 more
TL;DR: This review shows how specific oxidation products, deriving from polyunsaturated fatty acids precursors, are strictly related to the clinical manifestations and the natural history of Rett syndrome, a genetically determined neurodevelopmental pathology, currently classified among the autism spectrum disorders.
Journal ArticleDOI
Untargeted Metabolomics for Autism Spectrum Disorders: Current Status and Future Directions.
Kevin E. Glinton,Sarah H. Elsea +1 more
TL;DR: The principles and methodology behind untargeted metabolomics, recent pilot studies utilizing this technology, and areas in which it may be integrated into the care of children with this disorder in the future are reviewed.
Journal ArticleDOI
Redox Is a Global Biodevice Information Processing Modality
Eunkyoung Kim,Jinyang Li,Mijeong Kang,Deanna L. Kelly,Shuo Chen,Alessandra Napolitano,Lucia Panzella,Xiaowen Shi,Kun Yan,Si Wu,Jana Shen,William E. Bentley,Gregory F. Payne +12 more
TL;DR: Redox provides a unique ability to bridge biodevice communication because simple electrochemical methods enable global access to biologically meaningful information and it is envisioned that redox may facilitate the application of information theory to the biological sciences.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
The mitochondrial death/life regulator in apoptosis and necrosis
TL;DR: The acquisition of the biochemical and ultrastructural features of apoptosis critically relies on the liberation of apoptogenic proteases or protease activators from mitochondria.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
Journal ArticleDOI
Biological effects of the superoxide radical.
TL;DR: Can the superoxide radical exert deleterious effects independent of participating with H2O2 in the production of the hydroxyl radical?